IL-35 Receptor
The interleukin-35 receptor refers to the unusual receptor complexes through which the Treg-derived IL-12 family cytokine IL-35 transmits its suppressive signal. Unlike the canonical IL-12 and IL-23 receptors, IL-35 does not use a dedicated private subunit: it signals via two heterodimeric combinations-IL-12Rβ2 paired with gp130 (CD130), or IL-12Rβ2 paired with IL-12Rβ1-which are shared with other IL-12 family members. Ligand binding activates JAK1/JAK2 and TYK2, and uniquely drives the formation of STAT1-STAT4 and STAT1-STAT3 heterodimers (rather than STAT homodimers), which bind atypical GAS sites in target genes. This distinctive signaling architecture underlies IL-35's ability to suppress T-cell proliferation, blunt Th17 differentiation, and expand IL-35-producing induced regulatory T cells (iTr35). The composition of the IL-35 receptor differs between cell types, explaining tissue-specific responsiveness to IL-35 in autoimmunity, infection and cancer.
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IL-35 Receptor Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
