Proteasome Cap Targeting Chimeras
CAP-TACs
Proteasome Cap Targeting Chimeras (CAP-TACs) are a class of small-molecule-based bifunctional recruiting molecules. These molecules are capable of recruiting a diverse range of target proteins (POIs)—including BRD4, PRMT5, and FKBP12—to specific subunits within the 19S regulatory cap region (e.g., the RPN13 or RPN1 subunits). This recruitment subsequently induces the degradation of these POIs via a mechanism that is proteasome-dependent but ubiquitin-independent.
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Proteasome Cap Targeting Chimeras Related Products (3)
Related Products (3)
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RAPRMT5
0 ImagesCat. No.: HY-181521CAS No.: 2721998-42-9
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RAJQ14
0 ImagesCat. No.: HY-181495CAS No.: 2375455-53-9RAJQ14 is a BRD4 PROTAC-like CAP-TAC (Proteasome Cap Targeting Chimeras) degrader. RAJQ14 binds to 19S proteasome cap subunits RPN1, RPN10, RPN13, and USP14 to recruit target proteins to the proteasome for ubiquitination-independent, proteasome-dependent degradation. RAJQ14 can be used for the research of cancer (Pink: BRD4 Ligand (HY-181496); Blue: Proteasome Ligand (HY-128978); Black: Linker).
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RAFKBP12
0 ImagesCat. No.: HY-181498CAS No.: 2375455-59-5RAFKBP12 is a FKBP12 CAP-TAC (proteinase complex cap-targeted chimera) degrader. RAFKBP12 demonstrates the feasibility of the CAP-TAC strategy, which enables proteasome-dependent degradation of FKBP12 that is independent of E3 ubiquitin ligases and protein ubiquitination.
