Checkpoint Kinase 1 (Chk1)
Checkpoint Kinase 1 (Chk1, CHEK1) is a serine/threonine kinase that transduces the ATR-dependent replication stress and DNA damage checkpoint. Activated by ATR-mediated phosphorylation, Chk1 phosphorylates CDC25A, CDC25C, WEE1 and other substrates, enforcing S phase and G2/M arrest while homologous recombination repairs damaged DNA. Mouse embryos lacking Chk1 die early, underlining its essential role in genome maintenance. Because tumors with high replication stress are selectively vulnerable to checkpoint abrogation, Chk1 inhibitors have been combined with genotoxic chemotherapy and ATR inhibitors in oncology trials.
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Checkpoint Kinase 1 (Chk1) Recombinant Proteins (2)
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Inhibitors & Agonists (81)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
