1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. PPAR

PPAR

PPARs (Peroxisome proliferator-activated receptors) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/δ. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms. All PPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes. Activation of PPAR-α reduces triglyceride level and is involved in regulation of energy homeostasis. Activation of PPAR-γ enhances glucose metabolism, whereas activation of PPAR-β/δ enhances fatty acids metabolism.

PPAR Isoform Specific Products:

  • PPARα

  • PPARβ/δ

  • PPARγ

  • PPAR

PPAR Related Products (91):

Cat. No. Product Name Effect Purity
  • HY-17386
    Rosiglitazone Agonist 99.21%
    Rosiglitazone (BRL 49653) is a selective PPARγ agonist with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively.
  • HY-14649
    Retinoic acid Agonist 98.62%
    Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM.
  • HY-16578
    GW9662 Antagonist 99.53%
    GW9662 is a potent and selective PPARγ antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ, respectively.
  • HY-16737
    Elafibranor Agonist 99.18%
    Elafibranor is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.
  • HY-10838
    GW 501516 Agonist 99.27%
    GW 501516 is a PPARδ agonist with an EC50 of 1.1 nM.
  • HY-124108
    Eicosatetraynoic acid Activator
    Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively). Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 µM.
  • HY-128872
    VCE-​004.8 Agonist
    VCE-004.8, a semi-synthetic multitarget cannabinoquinoid, is a specific PPARγ and CB2 receptor dual agonist with potent anti-inflammatory activity. VCE-004.8 inhibits prolyl-hydroxylases (PHDs) and activates the HIF pathway. VCE-004.8 attenuates adipogenesis and prevents diet-induced obesity.
  • HY-117727
    Leriglitazone Antagonist
    Leriglitazone (Hydroxypioglitazone), a metabolite of pioglitazone. Leriglitazone (Hydroxypioglitazone) PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy. Leriglitazone (Hydroxypioglitazone) binds to the PPARγ C-terminal ligand-binding domain (LBD) with Ki of 1.2 μM,induces transcriptional efficacy of the PPARγ (LBD) with EC50 of 680 nM.
  • HY-13202
    T0070907 Antagonist 99.34%
    T0070907 is a potent PPARγ antagonist with a Ki of 1 nM.
  • HY-50935
    Troglitazone Agonist 99.53%
    Troglitazone is a PPARγ agonist, with EC50s of 550 nM and 780 nM for human and murine PPARγ receptor, respectively.
  • HY-17356
    Fenofibrate Agonist 99.92%
    Fenofibrate is a PPARα agonist with an EC50 of 30 μM.
  • HY-17618
    Pemafibrate Agonist 99.92%
    Pemafibrate is a highly selective PPARα agonist, with an EC50 of 1 nM.
  • HY-14601
    Pioglitazone hydrochloride Agonist
    Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC50s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively.
  • HY-N0182
    Fisetin Inhibitor 98.02%
    Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
  • HY-15372
    GW 6471 Antagonist 98.98%
    GW 6471 is a potent PPARα antagonist.
  • HY-N0014
    Icariin Activator 98.75%
    Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator.
  • HY-13956
    Pioglitazone Activator 99.18%
    Pioglitazone is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively.
  • HY-16995
    Pirinixic acid Agonist 99.48%
    Pirinixic acid (Wy-14643) is a potent agonist of PPARα, with EC50s of 0.63 μM, 32 μM for murine PPARα and PPARγ, and 5.0 μM, 60 μM, 35 μM for human PPARα, PPARγ and PPARδ, respectively.
  • HY-15655
    GW1929 Agonist 99.64%
    GW1929 is a potent PPAR-γ agonist, with a pKi of 8.84 for human PPAR-γ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively.
  • HY-15725
    CDDO-Im Activator 98.20%
    CDDO-Im (CDDO-imidazolide) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ.
Isoform Specific Products

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