1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. PPAR

PPAR

PPARs (Peroxisome proliferator-activated receptors) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/δ. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms. All PPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes. Activation of PPAR-α reduces triglyceride level and is involved in regulation of energy homeostasis. Activation of PPAR-γ enhances glucose metabolism, whereas activation of PPAR-β/δ enhances fatty acids metabolism.

PPAR Isoform Specific Products:

  • PPARα

  • PPARβ/δ

  • PPARγ

  • PPAR

PPAR Related Products (97):

Cat. No. Product Name Effect Purity
  • HY-17386
    Rosiglitazone Agonist 99.21%
    Rosiglitazone (BRL 49653) is a selective PPARγ agonist with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively.
  • HY-14649
    Retinoic acid Agonist 99.74%
    Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM.
  • HY-16578
    GW9662 Antagonist 99.53%
    GW9662 is a potent and selective PPARγ antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ, respectively.
  • HY-16737
    Elafibranor Agonist 99.18%
    Elafibranor is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.
  • HY-50935
    Troglitazone Agonist 99.53%
    Troglitazone is a PPARγ agonist, with EC50s of 550 nM and 780 nM for human and murine PPARγ receptor, respectively.
  • HY-130644
    iRucaparib-AP6 Inhibitor
    iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC approach. iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1.
  • HY-N0292
    Oleuropein Inhibitor 98.54%
    Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase.
  • HY-108568
    15-Deoxy-Δ-12,14-prostaglandin J2 Agonist
    15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM.
  • HY-13202
    T0070907 Antagonist 99.34%
    T0070907 is a potent PPARγ antagonist with a Ki of 1 nM.
  • HY-17356
    Fenofibrate Agonist 99.92%
    Fenofibrate is a PPARα agonist with an EC50 of 30 μM.
  • HY-10838
    GW 501516 Agonist 99.27%
    GW 501516 is a PPARδ agonist with an EC50 of 1.1 nM.
  • HY-15372
    GW 6471 Antagonist 98.98%
    GW 6471 is a potent PPARα antagonist.
  • HY-14601
    Pioglitazone hydrochloride Agonist
    Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC50s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively.
  • HY-N0182
    Fisetin Inhibitor 98.02%
    Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
  • HY-13956
    Pioglitazone Activator 99.18%
    Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively.
  • HY-N0014
    Icariin Activator 98.75%
    Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator.
  • HY-16995
    Pirinixic acid Agonist 99.48%
    Pirinixic acid (Wy-14643) is a potent agonist of PPARα, with EC50s of 0.63 μM, 32 μM for murine PPARα and PPARγ, and 5.0 μM, 60 μM, 35 μM for human PPARα, PPARγ and PPARδ, respectively.
  • HY-15725
    CDDO-Im Activator 98.20%
    CDDO-Im (CDDO-imidazolide) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ.
  • HY-N0100
    Naringenin 98.72%
    Naringenin is the predominant flavanone in grapefruit; displays strong anti-inflammatory and antioxidant activities.
  • HY-15721
    FH535 Inhibitor 99.93%
    FH535 is an inhibitor of Wnt/β-catenin and PPAR, with anti-tumor activities.
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.