2. Signaling Pathways
  3. JAK/STAT Signaling
    Stem Cell/Wnt
  4. STAT
  5. STAT3 Isoform

STAT3

 

STAT3 Related Products (85):

Cat. No. Product Name Effect Purity
  • HY-13818
    Stattic
    		Inhibitor 98.92%
    Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727).
  • HY-12000
    AG490
    		Inhibitor 99.97%
    AG490 (Tyrphostin AG490) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
  • HY-N0193
    Artesunate
    		Inhibitor ≥98.0%
    Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).
  • HY-B0497
    Niclosamide
    		Inhibitor 99.90%
    Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research.
  • HY-16141
    Cilengitide
    		Inhibitor 99.36%
    Cilengitide (EMD 121974) is a potent integrins antagonist with IC50s of 0.61 nM (ανβ3), 8.4 nM (ανβ5) and 14.9 nM (α5β1), respectively.
  • HY-103692
    STX-0119
    		Inhibitor 99.21%
    STX-0119 is a selective, orally active STAT3 dimerization inhibitor.
  • HY-148748
    Butyzamide
    		Activator
    Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor.
  • HY-151976
    STAT3-IN-15
    		Inhibitor
    STAT3-IN-15 is a potent and orally active STAT.html" class="link-product" target="_blank">STAT3 inhibitor against idiopathic pulmonary fibrosis (IPF).
  • HY-14944
    Homoharringtonine
    		Inhibitor 99.96%
    Homoharringtonine is a cytotoxic alkaloid, induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells.
  • HY-P1061A
    Colivelin TFA
    		Activator 99.22%
    Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro.
  • HY-10074
    TPCA-1
    		Inhibitor 99.72%
    TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM.
  • HY-112288
    C188-9
    		Inhibitor 99.90%
    C188-9 (TTI-101) is a STAT3 inhibitor, with a Kd of 4.7 nM.
  • HY-13919
    Napabucasin
    		Inhibitor 99.27%
    Napabucasin (BBI608) is a STAT3 inhibitor which blocks stem cell activity in cancer cells.
  • HY-15312
    WP1066
    		Inhibitor 99.90%
    WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3.
  • HY-N0174
    Cryptotanshinone
    		Inhibitor 98.69%
    Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities.
  • HY-15146
    NSC 74859
    		Inhibitor 98.64%
    NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC50 of 86 μM.
  • HY-129602
    SD-36
    		Inhibitor 99.46%
    SD-36 is a potent and efficacious STAT3 PROTAC degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members.
  • HY-N0751
    Scutellarin
    		Inhibitor 98.56%
    Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.
  • HY-12987
    Pimozide
    		Inhibitor 99.88%
    Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.
  • HY-B2163
    Astaxanthin
    		Inhibitor ≥98.0%
    Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant.