UCH Proteins
The UCH (ubiquitin C-terminal hydrolase) family is a small branch of cysteine deubiquitinases comprising UCHL1, UCHL3, UCHL5 (UCH37) and the non-classical member BAP1. All share a catalytic ubiquitin C-terminal hydrolase domain of the papain-like fold with a Cys-His-Asp triad, and most additionally contain a crosslink (UCL) domain that restricts them to small ubiquitin adducts and chain ends. UCHL1 is neuron-specific and implicated in Parkinson's disease, UCHL3 is broadly expressed, and proteasome-associated UCHL5 trims chains during substrate degradation. Their preference for disassembling ubiquitin from small conjugates distinguishes them from the larger USP and OTU families, and UCH proteins are common targets of activity-based probes.
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UCH Recombinant Proteins (6)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
