1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. PGC-1α

PGC-1α

PPARγ coactivator-1α

Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) serves as an inducible coregulator in the control of energy homeostasis. PGC-1α is a powerful transcriptional coregulator of GLUT4 and mitochondrial genes, including components of the electron transport system. PGC-1α is expressed abundantly in tissues with high energy demand, including brown adipose tissue, heart, skeletal muscle, kidney, and brain. PGC-1α has been shown to regulate adaptive thermogenesis, mitochondrial biogenesis, glucose and fatty acid metabolism, the peripheral circadian clock, fiber-type switching in skeletal muscle, and heart development. PGC-1α, a critical booster of mitochondrial function, is an excellent candidate for preventing insulin resistance and metabolic syndromes secondary to mitochondrial dysfunction. PGC-1α has been shown to influence energy metabolism.

PGC-1α Related Products (9):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101491
    SR-18292
    Inhibitor 99.82%
    SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.
    SR-18292
  • HY-17538
    ZLN005
    Activator 99.94%
    ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α).
    ZLN005
  • HY-N7439
    Mogroside VI B
    Activator 98.97%
    Mogroside VI B, a cucurbitane glucoside, separated from the crude extract of Siraitia grosvenorii. Mogroside VI B shows effect on activating PGC-1α transcription.
    Mogroside VI B
  • HY-P5763
    Phoenixin-20
    99.68%
    Phoenixin-20 (PNX-20) is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. Phoenixin-20 promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. Phoenixin-20 has anxiolytic effect.
    Phoenixin-20
  • HY-P3455
    Ac-SVVVRT-NH2
    Modulator 98.50%
    Ac-SVVVRT-NH2 is a PGC-1α modulator that modulates the activity of the human PGC-1α promoter (114%). Ac-SVVVRT-NH2 increases PGC-1α mRNA (125%) and accumulation of intracellular lipids (128%) in subcutaneous human adipocytes. Ac-SVVVRT-NH2 can be used in the research of diseases which is modulated by PGC-1α.
    Ac-SVVVRT-NH2
  • HY-P5763A
    Phoenixin-20 TFA
    Phoenixin-20 (TFA) (PNX-20 (TFA)) is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. Phoenixin-20 (TFA) promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. Phoenixin-20 (TFA) has anxiolytic effect.
    Phoenixin-20 TFA
  • HY-P5225
    Acetyl hexapeptide-38
    Inducer
    Acetyl hexapeptide-38 is a bioactive peptide with upregulate adipogenesis effect and has been reported used as a cosmetic ingredient.
    Acetyl hexapeptide-38
  • HY-17538S
    ZLN005-d4
    Activator 99.52%
    ZLN005-d4 is deuterium labeled ZLN005. ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α)[1].
    ZLN005-d<sub>4</sub>
  • HY-N12011
    11-Oxoisomogroside V
    Activator
    11-Oxoisomogroside V (compound 3) is a cucurbitacin isolated from the crude extract of Luo Han Guo. 11-Oxoisomogroside V activates the transcriptional activity of PGC-1α. In the luciferase experiment, the results showed that 10 μM and 20 μM 11-Oxoisomogroside V could increase the luciferase activity to 133.79% and 143.81%.
    11-Oxoisomogroside V