1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. PGC-1α

PGC-1α

Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) serves as an inducible coregulator in the control of energy homeostasis. PGC-1α is a powerful transcriptional coregulator of GLUT4 and mitochondrial genes, including components of the electron transport system. PGC-1α is expressed abundantly in tissues with high energy demand, including brown adipose tissue, heart, skeletal muscle, kidney, and brain. PGC-1α has been shown to regulate adaptive thermogenesis, mitochondrial biogenesis, glucose and fatty acid metabolism, the peripheral circadian clock, fiber-type switching in skeletal muscle, and heart development. PGC-1α, a critical booster of mitochondrial function, is an excellent candidate for preventing insulin resistance and metabolic syndromes secondary to mitochondrial dysfunction. PGC-1α has been shown to influence energy metabolism.

PGC-1α Related Products (2):

Cat. No. Product Name Effect Purity
  • HY-17538
    ZLN005 Activator 99.69%
    ZLN005 is a potent transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α).
  • HY-101491
    SR-18292 Inhibitor >98.0%
    SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.
Isoform Specific Products

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