1. Stem Cell/Wnt
  2. Wnt

Wnt

The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell. Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three Wnt signaling pathways are activated by the binding of a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the protein Dishevelled inside the cell. The canonical Wnt pathway leads to regulation of gene transcription, the noncanonical planar cell polarity pathway regulates the cytoskeleton that is responsible for the shape of the cell, and the noncanonical Wnt/calcium pathway regulates calcium inside the cell. The clinical importance of Wnt signaling pathway has been demonstrated by mutations that lead to a variety of diseases, including breast and prostate cancer, glioblastoma, type II diabetes.

Wnt Related Products (32):

Cat. No. Product Name Effect Purity
  • HY-14428
    ICG-001 Inhibitor 99.83%
    ICG-001 is an inhibitor of β-catenin/TCF mediated transcription. It works by specifically binding to cyclic AMP response element-binding protein with an IC50 of 3 μM.
  • HY-15597
    Salinomycin Inhibitor >98.0%
    Salinomycin is an anticoccidial drug with potent anti-bacterial activity and an novel anticancer agent targeting human cancer stem cells.
  • HY-12238
    IWR-1 Inhibitor 99.83%
    IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
  • HY-15659
    Wnt-C59 Inhibitor 99.56%
    Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM.
  • HY-17577
    Berberine chloride hydrate Activator 99.56%
    Berberine chloride hydrate is an alkaloid in several plants with various biological functions, including anti-inflammatory, and anti-oxidant activity. Berberine chloride hydrate is an AMPK activator.
  • HY-101275
    EMT inhibitor-1 Inhibitor 98.71%
    EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.
  • HY-75342
    Methyl vanillate Activator >98.0%
    Methyl vanillate, one of the ingredients in Hovenia dulcis Thunb, is a Wnt/β-catenin pathway activator. A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.
  • HY-A0293
    Pyrvinium pamoate Inhibitor >98.0%
    Pyrvinium pamoate is an FDA-approved antihelmintic drug that inhibits WNT pathway signaling.
  • HY-101916
    Heparan Sulfate
    Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.
  • HY-19987
    BML-284 Activator 99.98%
    BML-284 is selective and cell-permeable Wnt signaling activator.
  • HY-18988
    ETC-159 Inhibitor 98.67%
    ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
  • HY-13912
    IWP-2 Inhibitor
    IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM.
  • HY-100830
    NCB-0846 Inhibitor 99.55%
    NCB-0846 is an orally available TNIK inhibitor with an IC50 of 21 nM.
  • HY-101090
    KYA1797K Inhibitor >98.0%
    KYA1797K is a potent and selective Wnt/β-catenin inhibitor with an IC50 of 0.75 µM.
  • HY-15721
    FH535 Inhibitor 99.93%
    FH535 is an inhibitor of Wnt/β-catenin and PPAR, with anti-tumor activities.
  • HY-101085
    SKL2001 Agonist 98.08%
    SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity.
  • HY-16665
    iCRT 14 Inhibitor 98.90%
    iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT), with IC50 of 40.3 nM against Wnt responsive STF16 luciferase.
  • HY-12681
    CCT251545 Inhibitor 99.34%
    CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM.
  • HY-N0400
    Wogonin Inhibitor 99.83%
    Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt, and exhibits anti-inflammatory and anti-tumor effects.
  • HY-103705
    iCRT3 Inhibitor 99.19%
    iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription.
Isoform Specific Products

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