Fc epsilon RII/CD23
Fc epsilon receptor (FcεR) is the Fc receptor that binding immunoglobulin E (IgE). There are two types of FcεRs, called Fc epsilon RI (FcεRI) and Fc epsilon receptor II (FcεRII/CD23). FcεRII/CD23 is the low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses. FcεRII/CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities. As a membrane protein, FcεRII/CD23 is a type II transmembrane glycoprotein of approximately 45 kDa molecular weight comprising a large C-terminal globular extracellular domain that is strikingly similar to C-type lectins, followed by a stalk region bearing several repeats that serve as a putative leucine zipper that are important in CD23 oligomerization; the stalk region is followed by a short extracellular sequence (in human CD23), a single hydrophobic membrane-spanning region and a short N-terminal cytoplasmic domain. FcεRII/CD23 is expressed in T and B lymphocytes, polymorphonuclear leucocytes, monocytes, follicular dendritic cells, intestinal epithelial cells and bone marrow stromal cells, and its expression to subject to regulation by a number of stimuli.
-
Fc epsilon RII/CD23 Recombinant Proteins (3)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
