1. Cell Cycle/DNA Damage
  2. Checkpoint Kinase (Chk)

Checkpoint Kinase (Chk)

Checkpoint Kinases (Chk) are protein kinases that are involved in cell cycle control. Two checkpoint kinase subtypes have been identified, Chk1 and Chk2. Chk1 is a central component of genome surveillance pathways and is a key regulator of the cell cycle and cell survival. Chk1 is required for the initiation of DNA damage checkpoints and has recently been shown to play a role in the normal (unperturbed) cell cycle. Chk1 impacts various stages of the cell cycle including the S phase, G2/M transition and M phase. In addition to mediating cell cycle checkpoints, Chk1 also contributes to DNA repair processes, gene transcription, embryo development, cellular responses to HIV infection and somatic cell viability. Chk2 is a protein kinase that is activated in response to DNA damage and is involved in cell cycle arrest. In response to DNA damage and replication blocks, cell cycle progression is halted through the control of cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor.

Checkpoint Kinase (Chk) Related Products (14):

Cat. No. Product Name Effect Purity
  • HY-18174
    LY2606368 Inhibitor 99.13%
    LY2606368 is a potent and selective ATP competitive inhibitor of the Chk1 protein kinase, with a Ki of 0.9 nM against purified CHK1.
  • HY-10992
    AZD-7762 Inhibitor 98.68%
    AZD-7762 is a potent ATP-competitive checkpoint kinase (Chk) inhibitor in with IC50 of 5 nM for Chk1.
  • HY-14715B
    CCT241533 hydrochloride Inhibitor 99.62%
    CCT241533 hydrochloride is a potent and selective ATP competitive inhibitor of CHK2 with an IC50 of 3 nM and Ki of 1.16 nM.
  • HY-15532
    SCH900776 Inhibitor 99.65%
    SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with IC50 of 3 nM, and has much greater selectivity against Chk2 (IC50=1500 nM) and cyclin-dependent kinase CDK2 (IC50=160 nM).
  • HY-14720
    LY2603618 Inhibitor 99.61%
    LY2603618 is a potent and selective inhibitor of Chk1 protein kinase activity in vitro with IC50 of 7 nM.
  • HY-U00345
    CHK-IN-1 Inhibitor
    CHK-IN-1 is an inhibitor of CHK1 and CHK2, with anti-proliferative activities.
  • HY-18958
    CCT245737 Inhibitor 99.17%
    CCT245737 is a potent, ATP-competitive CHK1 inhibitor with an IC50 of 30-220 nM.
  • HY-13263
    CHIR-124 Inhibitor 98.77%
    CHIR-124 is a potent and selective Chk1 inhibitor with IC50 of 0.3 nM, and also potently targets PDGFR and FLT3 with IC50s of 6.6 nM and 5.8 nM.
  • HY-18174A
    LY2606368 dihydrochloride Inhibitor 99.74%
    LY2606368 dihydrochloride is a potent and selective ATP competitive inhibitor of the Chk1 protein kinase, with a Ki of 0.9 nM against purified CHK1.
  • HY-10032
    PF 477736 Inhibitor 98.04%
    PF-477736 is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes; shows ~100-fold selectivity for Chk1 than Chk2.
  • HY-13946
    BML-277 Inhibitor
    BML-277 (C 3742) is a selective Chk2 (checkpoint kinase 2) inhibitor with an IC50 of 15 nM.
  • HY-18175
    CCT244747 Inhibitor >98.0%
    CCT244747 is potent, highly selective, orally active, ATP competitive CHK1 inhibitor with IC50 of 29-170nM.
  • HY-14715
    CCT241533 Inhibitor
    CCT241533 is a potent and selective ATP competitive inhibitor of CHK2 with an IC50 of 3 nM and Ki of 1.16 nM.
  • HY-15532B
    SCH900776 S-isomer
    SCH900776 S-isomer is the S-isomer of SCH900776.