1. Cell Cycle/DNA Damage
  2. Checkpoint Kinase (Chk)

Checkpoint Kinase (Chk)

Checkpoint Kinases (Chk) are protein kinases that are involved in cell cycle control. Two checkpoint kinase subtypes have been identified, Chk1 and Chk2. Chk1 is a central component of genome surveillance pathways and is a key regulator of the cell cycle and cell survival. Chk1 is required for the initiation of DNA damage checkpoints and has recently been shown to play a role in the normal (unperturbed) cell cycle. Chk1 impacts various stages of the cell cycle including the S phase, G2/M transition and M phase. In addition to mediating cell cycle checkpoints, Chk1 also contributes to DNA repair processes, gene transcription, embryo development, cellular responses to HIV infection and somatic cell viability. Chk2 is a protein kinase that is activated in response to DNA damage and is involved in cell cycle arrest. In response to DNA damage and replication blocks, cell cycle progression is halted through the control of cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor.

Checkpoint Kinase (Chk) Isoform Specific Products:

  • Chk1

  • Chk2

Checkpoint Kinase (Chk) Related Products (15):

Cat. No. Product Name Effect Purity
  • HY-18174
    LY2606368 Inhibitor 99.13%
    LY2606368 is a potent and selective ATP competitive inhibitor of the Chk1 protein kinase, with IC50s of <1 nM and 8 nM for CHK1 and CHK2, respectively, and a Ki of 0.9 nM against purified CHK1.
  • HY-10992
    AZD-7762 Inhibitor 98.68%
    AZD-7762 is a potent ATP-competitive checkpoint kinase (Chk) inhibitor in with IC50 of 5 nM for Chk1.
  • HY-14720
    LY2603618 Inhibitor 99.61%
    LY2603618 is a potent and selective inhibitor of Chk1 protein kinase activity in vitro with IC50 of 7 nM.
  • HY-14715B
    CCT241533 hydrochloride Inhibitor 99.62%
    CCT241533 hydrochloride is a potent and selective ATP competitive inhibitor of CHK2 with an IC50 of 3 nM and Ki of 1.16 nM.
  • HY-15532
    SCH900776 Inhibitor 99.65%
    SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with IC50 of 3 nM, and has much greater selectivity than Chk2 (IC50=1500 nM) and cyclin-dependent kinase CDK2 (IC50=160 nM).
  • HY-112167
    GDC-0575 Inhibitor
    GDC-0575 (ARRY-575, RG7741) is a highly-selective oral small-molecule Chk1 inhibitor with an IC50 of 1.2 nM.
  • HY-104022
    CHK1 inhibitor
    CHK1 inhibitor is an inhibitor of CHK1.
  • HY-18958
    CCT245737 Inhibitor 99.24%
    CCT245737 is a orally active and seletive Chk1 inhibitor, with an IC50 of 1.3 nM; CCT245737 shows much less activity against Chk2, with an IC50 of 2440 nM.
  • HY-18174A
    LY2606368 dihydrochloride Inhibitor 99.74%
    LY2606368 dihydrochloride is a potent and selective ATP competitive inhibitor of the Chk1 protein kinase, with IC50s of <1 nM and 8 nM for CHK1 and CHK2, respectively, and a Ki of 0.9 nM against purified CHK1.
  • HY-13263
    CHIR-124 Inhibitor 98.77%
    CHIR-124 is a potent and selective Chk1 inhibitor with IC50 of 0.3 nM, and also potently targets PDGFR and FLT3 with IC50s of 6.6 nM and 5.8 nM.
  • HY-10032
    PF 477736 Inhibitor 98.04%
    PF 477736 is a potent, selective ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, 100-fold selectivity versus Chk2 (Ki, 47 nM).
  • HY-13946
    BML-277 Inhibitor
    BML-277 is a selective checkpoint kinase 2 (Chk2) inhibitor with an IC50 of 15 nM.
  • HY-18175
    CCT244747 Inhibitor 98.03%
    CCT244747 is a potent, orally bioavailable and highly selective CHK1 inhibitor, with an IC50 of 7.7 nM; CCT244747 also abrogates G2 checkpoint with an IC50 of 29 nM.
  • HY-14715
    CCT241533 Inhibitor
    CCT241533 is a potent and selective ATP competitive inhibitor of CHK2 with an IC50 of 3 nM and Ki of 1.16 nM.
  • HY-U00345
    CHK-IN-1 Inhibitor
    CHK-IN-1 is an inhibitor of CHK1 and CHK2, with anti-proliferative activities.
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.