IL-1R1/CD121a
IL-1R1 (CD121a), a member of IL-1 receptor, is a receptor for IL-1α, IL-1β, IL-1Ra and IL-38[1]. IL-1R1 mediates immune and inflammatory responses.IL-1R1 mediates IL-1-dependent activation, including the activation of NF-κB and MAPK pathway[2]. IL-1R1 is expressed in specific endothelial cells, ventricular cells, astrocytes, and neurons[3]. Human IL-1R1 consists of extracellular domain (L18-K336), helical domain (H337-Y356), and cytoplasmic domain (K357-G569).Human IL-1R1 shares <70% aa sequence identity with mouse and rats. Rats IL-1R1 shares 85.59% aa sequence identity with mouse. IL-1R1 binds to IL-1 by forming a heterodimer with IL-1R3 (IL-1RAcP). The heterodimer is responsible for the signal transduction by the hydrolysis of GTP, followed by the activation of JNK and p38 MAP kinase[4]. Upon binding of IL-1, IL-1R1 initiates the downstream signaling cascade (MAPK p38 and NF-κB pathway)[2].
- [1]. Diana Boraschi, et al. The family of the interleukin-1 receptors. Immunol Rev. 2018 Jan;281(1):197-232. [Content Brief]
- [2]. Yonggang Sha, et al. A role of IL-1R1 signaling in the differentiation of Th17 cells and the development of autoimmune diseases. Self Nonself. 2011 Jan;2(1):35-42. [Content Brief]
- [3]. Daniel P Nemeth, et al. Modulation of Neural Networks by Interleukin-1. Brain Plast. 2021 Aug 23;7(1):17-32. [Content Brief]
- [4]. Naoe Kaneko, et al. The role of interleukin-1 in general pathology. Inflamm Regen. 2019 Jun 6;39:12. [Content Brief]
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IL-1R1/CD121a Recombinant Proteins (9)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
