Signaling Pathway

DNA Methyltransferase

DNA Methyltransferase

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DNA Methyltransferase Inhibitors & Modulators (9)

Product Name Catalog No. Brief Description
DC_05

HY-12746

DC_05 is a non-nucleoside DNMT1 inhibitor(IC50=10.3 uM) with low micromolar IC50 values and significant selectivity toward other AdoMet-dependent protein methyltransferases.

DC_517

HY-12747

DC_517 is a novel selective non-nucleoside inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 = 1.7 μM).

Decitabine

HY-A0004

Decitabine is a potent inhibitor of DNA methyltransferase with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively.

Glucose-conjugated MGMT inhibitor

HY-13057

O6BTG-C8-βGlu is a glucose-conjugated MGMT inhibitor with IC50 values of 32 nM in vitro and 10 nM on HeLa S3 cell; the parent compound O6BTG's IC50 is 9 nM(in vitro).

Lomeguatrib

HY-13668

Lomeguatrib (PaTrin-2) is a modified guanine base, which can  repress the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) with an IC50 value of 6 nM.

N-Acetylprocainamide

HY-B1109

N-Acetylprocainamide is the N-acetylated metabolite of Procainamide, it is a Class III antiarrhythmic agent, whereas procainamide is a Class Ia antiarrhythmic drug.

RG108

HY-13642

RG108 is a non-nucleoside inhibitor of DNA methyltransferase with IC50 of 115 nM.

SGI-1027

HY-13962

SGI-1027 is a potent and selective inhibitor of DNA methyltransferase (DNMT) with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B, respectively.

Zebularine

HY-13420

Zebularine(NSC309132; 4-Deoxyuridine) is a DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases, also inhibits cytidinedeaminase with Ki of 2 μM.