1. Metabolic Enzyme/Protease
  2. Phosphatase

Phosphatase

Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of both insulin and leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.

Phosphatase Related Products (40):

Cat. No. Product Name Effect Purity
  • HY-100388A
    SHP099 hydrochloride Inhibitor 99.67%
    SHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC50 of 70 nM.
  • HY-100388
    SHP099 Inhibitor 99.78%
    SHP099 is a potent, selective, orally available SHP2 inhibitor with an IC50 of 70 nM.
  • HY-15486
    Salubrinal Inhibitor 99.58%
    Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation.
  • HY-18983
    Calyculin A Inhibitor >98.0%
    Calyculin A is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.5 to 1 nM.
  • HY-100595
    Stibogluconate sodium Inhibitor >98.0%
    Stibogluconate sodium is a potent inhibitor of protein tyrosine phosphatase. Stibogluconate sodium inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10, 100, 100 μg/mL, respectively.
  • HY-116009
    RMC-4550 Inhibitor
    RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM.
  • HY-12728
    Tautomycin Inhibitor >98.0%
    Tautomycin, an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus, is a potent and specific inhibitor of protein phosphatases 1 and 2A and induces contraction of smooth muscle under Ca2+-free conditions, with Kiapp values of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively.
  • HY-114397
    SHP394 Inhibitor
    SHP394 is an orally efficacious protein tyrosine phosphatase SHP2 inhibitor with an IC50 of 23 nM.
  • HY-12219A
    MSI-1436 lactate Inhibitor
    MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein tyrosine phosphatase 1B (PTB-1B), with an IC50 of 1 μM, 200-fold preference over TC-PTP (IC50 of 224 μM).
  • HY-15842
    SF1670 Inhibitor >98.0%
    SF1670 is a potent and specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor.
  • HY-100463
    TPI-1 Inhibitor >98.0%
    TPI-1 is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM.
  • HY-D0852
    Sodium orthovanadate Inhibitor >99.0%
    Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.
  • HY-100462
    PTP1B-IN-2 Inhibitor 99.63%
    PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 50 nM.
  • HY-15832
    GSK 2830371 Inhibitor 98.94%
    GSK 2830371 is a highly selective Wip1 phosphatase inhibitor with IC50 of 6 nM.
  • HY-12219
    MSI-1436 Inhibitor
    MSI-1436 is a selective, non-competitive inhibitor of the enzyme protein tyrosine phosphatase 1B (PTB-1B), with an IC50 of appr 1 μM, 200-fold preference over TC-PTP (IC50, 224 μM).
  • HY-100034
    NSC 663284 Inhibitor >98.0%
    NSC 663284 is a Cdc25 dual specificity phosphatases inhibitor with an IC50 of 0.21 μM.
  • HY-109011
    Rosiptor Activator 99.54%
    Rosiptor is an activator of SH2-containing inositol-5'-phosphatase 1 (SHIP1).
  • HY-12312
    TCS 401 Inhibitor >98.0%
    TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).
  • HY-18667
    LTV-1 Inhibitor >98.0%
    LTV-1 is a highly potent, cell-permeable and reversible inhibitor of lymphoid tyrosine phosphatase (LYP) (IC50 = 508 nM).
  • HY-18685
    CPDA Inhibitor 99.11%
    CPDA is a novel potent SH2 domain-containing inositol phosphatase 2 (SHIP2) inhibitor that can effectively ameliorate insulin resistance in 3T3-L1 adipocytes.
Isoform Specific Products

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