60940-34-3
Chemical Structure
Ebselen
Synonym(s): SPI-1005; PZ-51; CCG-39161
- CAS No.: 60940-34-3
- Formula:C13H9NOSe
- Molecular Weight:274.18
IUPAC Name: 2-phenylbenzo[d][1,2]selenazol-3(2H)-one
InChIKey: DYEFUKCXAQOFHX-UHFFFAOYSA-N
SMILES: O=C1N(C2=CC=CC=C2)[Se]C3=C1C=CC=C3
Biological Activity: Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker[1][2]. Ebselen potently inhibits Mpro (IC50=0.67 μM) and COVID-19 virus (EC50=4.67 μM)[3].Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity[4][5].
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Ebselen | 99.80% | Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker. Ebselen potently inhibits Mpro (IC50=0.67 μM) and COVID-19 virus (EC50=4.67 μM).Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity. | ||||||||||||||||||||
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Ebselen (Standard) | ≥98% | Ebselen (Standard) is the analytical standard of Ebselen (HY-13750). This product is intended for research and analytical applications. Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker. Ebselen potently inhibits Mpro (IC50=0.67 μM) and COVID-19 virus (EC50=4.67 μM).Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity. | ||||||||||||||||||||
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Similarity Score 0.82
HY-179650NSD2-PWWP1-IN-5 -
Similarity Score 0.80
HY-143899FBA-IN-1 -
Similarity Score 0.77
HY-179651NSD2-PWWP1-IN-6 -
Similarity Score 0.76
HY-184667β-Lactamase/Ferroptosis-IN-1 -
Similarity Score 0.76
HY-141841SARS-CoV-2-IN-7 -
Similarity Score 0.69
HY-128170Ebsulfur -
Similarity Score 0.66
HY-114727PDE7-IN-4 -
Similarity Score 0.65
HY-157144SARS-CoV-2-IN-68 -
Similarity Score 0.64
HY-163506Ebselen derivative 1 -
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References
- [1]. Liang Q, et al. Electrical Stimulation Degenerated Cochlear Synapses Through Oxidative Stress in NeonatalCochlear Explants. Front Neurosci. 2019 Oct 14;13:1073. [Content Brief]
- [2]. H Sies, et al. Ebselen, a Selenoorganic Compound as Glutathione Peroxidase Mimic [Content Brief]
- [3]. Jin Z, et al. Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature. 2020 Apr 9. [Content Brief]
- [4]. Thenin-Houssier S, et al. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2195-208. [Content Brief]
- [5]. Singh N, et al. A safe lithium mimetic for bipolar disorder. Nat Commun. 2013;4:1332. doi: 10.1038/ncomms2320. [Content Brief]
