Alkaloids

Alkaloids are a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms, produced by a large variety of organisms including bacteria, fungi, plants, and animals. Compounds like amino acid peptides, proteins, nucleotides, nucleic acid, amines, and antibiotics are usually not called alkaloids. They are classified on the basis of the principal C-N skeleton structure which includes numerous subclasses of alkaloids namely, pyrrole, pyridine, quinoline, isoquinoline, indole and other alkaloids, etc. Alkaloids have a wide range of pharmacological activities including antimalarial, anti-asthmatic, anti-cancer, cholinomimetic, vasodilating, anti-arrhythmic, analgesic, anti-bacterial, and anti-diabetic activities. Many have found use in traditional or modern medicine, or as starting points for drug discovery. They possess potent pharmacological effects for eg. the well-known plant alkaloids include the narcotic analgesics, morphine and codeine, the muscle relaxant papaverine, and the antimicrobial agents sanguinarine and berberine. And some alkaloids are toxic.

Alkaloids (1272):

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-15141

Staurosporine	62996-74-1	99.98%
Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC₅₀s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC₅₀ of 3 μM. Staurosporine is an apoptosis inducer.

HY-B2176

ATP	56-65-5	≥98.0%
ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.

HY-B0150

Nicotinamide	98-92-0	99.87%
Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC₅₀: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD₊, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity.

HY-B0468

Isoprenaline hydrochloride	51-30-9	99.73%
Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma.

HY-A0190

Ceruletide	17650-98-5	99.96%
Ceruletide is a decapeptide and a potent cholecystokinin receptor agonist. Ceruletide is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts.

HY-N0926A

Columbamine chloride 1916-10-5 98.63%

Columbamine (Columbamin; Dehydroisocorypalmine) chloride is an alkaloid.
HY-W153159

N-Methyltyramine hydrochloride 13062-76-5 99.41%

N-Methyltyramine (hydrochloride) can be isolated from the plants of the Citrus genus.

Columbamine chloride	1916-10-5	98.63%
Columbamine (Columbamin; Dehydroisocorypalmine) chloride is an alkaloid.

N-Methyltyramine hydrochloride	13062-76-5	99.41%
N-Methyltyramine (hydrochloride) can be isolated from the plants of the Citrus genus.

HY-100355

C18-Ceramide	2304-81-6	99.95%
C18-Ceramide can promote exocytosis of glutamate from damaged neurons. C18-Ceramide promotes cell death in glioma cells. Ceramides is involved in diverse cellular functions, such as differentiation, cell cycle progression, cell-cell adhesion, senescence, and apoptosis.

HY-13704

SN-38 86639-52-3 99.89%

SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively.

SN-38	86639-52-3	99.89%
SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively.

HY-66005

Acetaminophen	103-90-2	99.98%
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-16560

Camptothecin	7689-03-4	99.82%
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells.

HY-N0488

Vincristine sulfate	2068-78-2	99.81%
Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a K_i of 85 nM.

HY-13768A

Topotecan hydrochloride 119413-54-6 99.76%

Topotecan Hydrochloride (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities.
HY-B0726

Pilocarpine Hydrochloride 54-71-7 99.98%

Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
HY-N2309

Kainic acid 487-79-6 99.90%

Kainic acid is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid induces seizures.

Topotecan hydrochloride	119413-54-6	99.76%
Topotecan Hydrochloride (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities.

Pilocarpine Hydrochloride	54-71-7	99.98%
Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

Kainic acid	487-79-6	99.90%
Kainic acid is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid induces seizures.

HY-123033A

Nicotinamide riboside chloride	23111-00-4	99.59%
Nicotinamide riboside Chloride, an orally active NAD⁺ precursor, increases NAD⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.

HY-N0750

Monocrotaline	315-22-0	99.98%
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC₅₀s of 36.8 µM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. ^[2][6][8].

HY-14944

Homoharringtonine 26833-87-4 99.96%

Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.

Homoharringtonine	26833-87-4	99.96%
Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.

HY-B0573

Propranolol hydrochloride	318-98-9	99.97%
Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.

HY-16562A

Irinotecan hydrochloride 100286-90-6 99.89%

Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer.

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