1. Cell Cycle/DNA Damage
  2. Microtubule/Tubulin

Vincristine sulfate (Synonyms: Leurocristine sulfate; 22-Oxovincaleukoblastine sulfate)

Cat. No.: HY-N0488 Purity: 99.51%
Handling Instructions

Vincristine (sulfate) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.

For research use only. We do not sell to patients.
Vincristine sulfate Chemical Structure

Vincristine sulfate Chemical Structure

CAS No. : 2068-78-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
10 mg USD 60 In-stock
50 mg USD 132 In-stock
100 mg USD 216 In-stock
200 mg USD 396 In-stock
500 mg   Get quote  
1 g   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Vincristine (sulfate) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.

In Vitro

Vincristine inhibits net addition of tubulin dimers at assembly ends of steady-state microtubules with Ki of 85 nM[1]. Vincristine stabilizes the spindle apparatus resulting in failure of the chromosomes to segregate leading to metaphase arrest and inhibition of mitosis at low concentrations. At higher concentrations, Vincristine may disrupt and induce total depolymerization of microtubules[2]. Vincristine induces apoptosis in tumor cells and inhibits SH-SY5Y cell proliferation with IC50 of 0.1 μM. Vincristine induces mitotic arrest and promots the expression of caspase-3 and -9 and cyclin B, while decreasing the expression of cyclin D[3]. Vincristine induced neurotoxicity is caused by interference with microtubule function, which results in blockage of axonal transport and thus in axonal degeneration[4]

In Vivo

Vincristine (3 mg/kg, i.p.) induces mean growth delay of > 120 and > 52 day, and repopulates fractions of 0.06% and 5%, administrated in mice bearing bilateral subcutaneous xenografts Rh12 or Rh18, respectively[5]

Clinical Trial
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.0834 mL 5.4169 mL 10.8338 mL
5 mM 0.2167 mL 1.0834 mL 2.1668 mL
10 mM 0.1083 mL 0.5417 mL 1.0834 mL
Please refer to the solubility information to select the appropriate solvent.
Cell Assay

Cells are plated in 2 mL of medium in 35 mm plates at a concentration of about 5×104 cells/mL and grow for 24 h at 37°C in an atmosphere of 5% CO2 and 95% air. Then medium is replaced with fresh medium lacking or containing 4 nM drug and proliferation is continued for 3 days. Cell counts are done each day in a Coulter Counter after detaching the cells with trypsin and EDTA. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







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4°C, protect from light


Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

Vincristine solution (dissolved with acetone) is mixed with PLGA solution[6].

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.


Purity: 99.51%

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