1. Signaling Pathways
  2. PI3K/Akt/mTOR
  3. MELK

MELK

Maternal embryonic leucine zipper kinase

MELK (Maternal embryonic leucine zipper kinase) belongs to the CAMK serine/threonine protein kinase superfamily. Melk is a protein serine/threonine kinase that is maximally active during mitosis. It is involved in diverse functions such as cell cycle, cytokinesis, mRNA splicing and apoptosis. Expression MELK is expressed in cells of various tissue origins. MELK expression is strongly dependant on cell-cycle: MELK is undetectable in cells which have exited cell cycle. The exact function of MELK is currently unknown, however MELK was shown to be involved in cell cycle progression via the protein phosphatase CDC25B phosphorylation, in cytokinesis, in apoptosis via its interaction with the Bcl-2 family of proapoptotic genes and apoptosis signal-regulating kinase (ASK1) and in inhibition of mRNA splicing during mitosis via its association with NIPP1. MELK function is required for mammary tumorigenesis in vivo.

MELK Related Products (7):

Cat. No. Product Name Effect Purity
  • HY-15512A
    OTSSP167 hydrochloride
    Inhibitor 99.84%
    OTSSP167 (OTS167) hydrochloride is a highly potent and ATP-competitive MELK inhibitor with IC50 value of 0.41 nM.
  • HY-100368A
    MELK-8a hydrochloride
    Inhibitor 99.26%
    MELK-8a hydrochloride is a novel maternal embryonic leucine zipper kinase (MELK) inhibitor with an IC50 of 2 nM.
  • HY-12420
    JNJ-47117096 hydrochloride
    Inhibitor 98.01%
    JNJ-47117096 hydrochloride is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM.
  • HY-122665
    HTH-01-091
    Inhibitor
    HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. HTH-01-091 also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be uesd for breast cancer research.
  • HY-15512
    OTSSP167
    Inhibitor
    OTSSP167 (OTS167) is a highly potent and ATP-competitive MELK inhibitor with IC50 value of 0.41 nM.
  • HY-100368
    MELK-8a
    Inhibitor
    MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC50s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells.
  • HY-101515
    MELK-IN-1
    Inhibitor
    MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 and a Ki of 3 nM and 0.39 nM, respectively.