2. Signaling Pathways
  3. Apoptosis
    Autophagy
  4. 14-3-3 Protein

14-3-3 Protein

Eukaryotic 14-3-3 Protein

14-3-3 proteins are conserved eukaryotic scaffolding proteins that primarily regulate target-protein function through phosphorylation-dependent binding[1]. Mechanistically, 14-3-3 recognizes phosphoserine-binding motifs and connects protein kinase signaling to protein-complex assembly, localization, and activity control[2][3]. Therefore, 14-3-3 participates in cell-cycle control, apoptosis, signal transduction, energy metabolism, and protein trafficking[1][4]. In disease models, the 14-3-3 interaction network regulates cancer-relevant apoptosis, cell-cycle progression, autophagy, glucose metabolism, and cell motility[5]. Compared with broadly expressed 14-3-3β, γ, ε, ζ, η, and τ, 14-3-3σ shows stronger relevance to cell-cycle and tumor-suppressor biology in cancer research[4][6]. 14-3-3η also acts as a serum biomarker in rheumatoid arthritis by complementing RF and ACPA testing and associating with worse disease[7]. For experimental applications, small-molecule modulators of 14-3-3 proteins support studies of protein interactions, cell cycle, apoptosis, and disease-linked signaling pathways[8].14-3-3 proteins connect phosphorylation-dependent binding with cell-cycle, apoptosis, metabolism, and trafficking research.
Isoform-focused studies distinguish 14-3-3σ cancer biology from 14-3-3η rheumatoid arthritis biomarkers.
14-3-3 modulators enable protein-protein interaction, signaling pathway, and disease model experiments.

14-3-3 Protein Isoform Specific Products:

14-3-3 Protein Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12462
    WS3
    		Inhibitor 98.70%
    WS3 is an allosteric inhibitor of 14-3-3 (14-3-3ζ: Kd = 2.29 μM). WS3 activates GSK3β by disrupting the binding of 14-3-3-pGSK3β, promotes the ubiquitination and degradation of NRF2, and inhibits the NRF2-ARE signaling pathway (IC50 = 135 nM). It exerts antioxidant inhibition and chemotherapeutic/ferroptosis sensitizing effects in tumors with hyperactivated NRF2. WS3 binds to EBP1/IKKε and promotes the proliferation of β cells and retinal pigment epithelial (RPE) cells, which can be applied to islet regeneration and RPE expansion transplantation. WS3 is applicable to research related to age-related macular degeneration, retinal degeneration and non-small cell lung cancer.
    WS3
  • HY-115501
    (E)-FOBISIN101
    		Inhibitor
    (E)-FOBISIN101 is a 14-3-3 protein-protein interaction (14-3-3 protein-protein interaction) inhibitor, with IC50 values of 9.3 and 16.4 μM for disrupting the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively. (E)-FOBISIN101 inhibits the binding of 14-3-3 to Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exotoxin S ADP-ribosyltransferase. (E)-FOBISIN101 is applicable to 14-3-3-mediated cancer research.
    (E)-FOBISIN101
  • HY-146302
    14-3-3η Protein inhibitor 1
    		Inhibitor 99.00%
    14-3-3η Protein inhibitor 1 (Compound C11) is a 14-3-3η protein inhibitor with a KD of 35 µM. 14-3-3η Protein inhibitor 1 shows inhibitory activities against several typical human liver cancer cell lines. 14-3-3η Protein inhibitor 1 induces cell apoptosis and G1-S cell cycle arrest with good metabolic stability.
    14-3-3η Protein inhibitor 1
  • HY-177590
    14-3-3-IN-2
    		Inhibitor 98.41%
    14-3-3-IN-2 is a 14-3-3 protein inhibitor with an IC50 of 15 nM. 14-3-3-IN-2 can disrupt the interaction of 14-3-3α with aminopeptidase N and down-regulate 14-3-3α increased MMP-1 mRNA levels.
    14-3-3-IN-2
  • HY-N13798
    ADHPE
    		Inducer
    ADHPE is a stabilizer of 14-3-3σ and p65 protein complex. ADHPE inhibits NF-κB (p65) signaling pathway and reduces the inflammatory response. ADHPE can be used for pediatric pneumonia-related acute lung injury and acute respiratory distress syndrome study.
    ADHPE
  • HY-179576
    CV2a
    		Modulator
    CV2a is a 14-3-3-directed molecular glue-based PROTAC that selectively targets the ERα protein complex with an EC50 of 0.10 μM. CV2a cooperatively recruits VHL to the 14-3-3/ERα complex and promotes robust polyubiquitination of the 14-3-3ζ/ERα complex.
    CV2a
  • HY-171977
    UTKO1
    		Inhibitor
    UTKO1 (Compound 2) is a derivate of Moverastin.UTKO1 has optical activity and significant inhibitory activity against tumor cell migration by abrogating the binding of 14-3-3ζ/Tiam1. UTKO1 can be used for cancers like esophageal cancer and epidermoid carcinoma research.
    UTKO1
  • HY-162838
    TCF199
    		Inducer
    TCF199 is an allosteric stabilizer that stabilizes the 14-3-3/TAZ peptide interaction, binding to the 14-3-3ζ/E R α peptide and 14-3-3ζ/Chibby peptide. TCF199 has a Kd value of 122 μM for its interaction with 14-3-3/TAZ.
    TCF199
  • HY-175872
    14-3-3σ/ERα stabilizer-2
    		Inducer
    14-3-3σ/ERα stabilizer-2 (Compound 41) is a covalent 14-3-3σ/ERα stabilizer with a Kd of 10.1 nM. 14-3-3σ/ERα stabilizer-2 significantly decreases the dissociation rate of ERα, stabilizing the binary ERα/14-3-3σ interaction. 14-3-3σ/ERα stabilizer-2 can be used for molecular glues research.
    14-3-3σ/ERα stabilizer-2
14-3-3 Protein Isoform Comparison

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