EN171

Cat. No.: HY-W1005067 Purity: 98.14%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol.

For research use only. We do not sell to patients.

EN171 Chemical Structure

CAS No. : 2191110-79-7

Size	Stock	Quantity
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Oil
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

or Bulk Inquiry

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This product is a controlled substance and not for sale in your territory.

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Hippo (MST) Isoform Specific Products:

View All Isoforms

MST1 MST2 MST3 MST4

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms

Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

270.37

Formula

C₁₇H₂₂N₂O

CAS No.

2191110-79-7

Appearance

Oil

Color

Colorless to off-white

SMILES

O=C(N1CCC2(CN(CC2)CC3=CC=CC=C3)C1)C=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (92.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6986 mL	18.4932 mL	36.9864 mL
5 mM	0.7397 mL	3.6986 mL	7.3973 mL
10 mM	0.3699 mL	1.8493 mL	3.6986 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.14%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (247 KB) HNMR (252 KB) LCMS (86 KB)

Handling Instructions (2659 KB)

References

[1]. Shao Q, et al. Targeted Protein Localization by Covalent 14-3-3 Recruitment. J Am Chem Soc. 2024 Sep 11;146(36):24788-24799. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.6986 mL	18.4932 mL	36.9864 mL	92.4659 mL
	5 mM	0.7397 mL	3.6986 mL	7.3973 mL	18.4932 mL
	10 mM	0.3699 mL	1.8493 mL	3.6986 mL	9.2466 mL
	15 mM	0.2466 mL	1.2329 mL	2.4658 mL	6.1644 mL
	20 mM	0.1849 mL	0.9247 mL	1.8493 mL	4.6233 mL
	25 mM	0.1479 mL	0.7397 mL	1.4795 mL	3.6986 mL
	30 mM	0.1233 mL	0.6164 mL	1.2329 mL	3.0822 mL
	40 mM	0.0925 mL	0.4623 mL	0.9247 mL	2.3116 mL
	50 mM	0.0740 mL	0.3699 mL	0.7397 mL	1.8493 mL
	60 mM	0.0616 mL	0.3082 mL	0.6164 mL	1.5411 mL
	80 mM	0.0462 mL	0.2312 mL	0.4623 mL	1.1558 mL

EN171 Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EN1712191110-79-7EN 171EN-171Molecular GluesHippo (MST)Estrogen Receptor/ERRcovalent ligand14-3-3ERαYAPTAZHippo pathwaymolecular glueInhibitorinhibitorinhibit

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