1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. DNA-PK

DNA-PK

DNA-PKcs (DNA-dependent protein kinase, catalytic subunit) is an enzyme that in humans is encoded by the PRKDC gene. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. DNA-PKcs is the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase called DNA-PK. The second component is the autoimmune antigen Ku. On its own, DNA-PKcs is inactive and relies on Ku to direct it to DNA ends and trigger its kinase activity. DNA-PKcs is required for the non-homologous end joining (NHEJ) pathway of DNA repair. Many proteins have been identified as substrates for the kinase activity of DNA-PK. Autophosphorylation of DNA-PKcs appears to play a key role in NHEJ and is thought to induce a conformational change that allows end processing enzymes to access the ends of the double-strand break. DNA-PK also cooperates with ATR and ATM to phosphorylate proteins involved in the DNA damage checkpoint.

DNA-PK Related Products (9):

Cat. No. Product Name Effect Purity
  • HY-10197
    Wortmannin Inhibitor 99.33%
    Wortmannin is a multi-target inhibitor of PI3K and MLCK with IC50s of 3 nM and 170 nM, respectively.
  • HY-12513
    LY3023414 Inhibitor 99.70%
    LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242).
  • HY-11006
    KU-57788 Inhibitor 98.74%
    KU-57788 is a potent and selective inhibitor of DNA-PK, a modest inhibitor of BRD4 and BRDT, with IC50s of 13 nM, 1 μM and 3.5 μM, respectively, and also increases CRISPR/Cas9-mediated editing frequencies.
  • HY-15719
    NU 7026 Inhibitor 99.94%
    NU 7026 is a novel specific DNA-PK inhibitor with IC50 of 0.23±0.01 μM, also inhibits PI3K with IC50 of 13±3 μM.
  • HY-13281
    PIK-75 Inhibitor 99.91%
    PIK-75 is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM.
  • HY-101667
    LTURM34 Inhibitor 99.24%
    LTURM34 is a specific DNA-PK inhibitor with an IC50 of 0.034 μM.
  • HY-16962
    CC-115 Inhibitor
    CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
  • HY-16962A
    CC-115 hydrochloride Inhibitor
    CC-115 hydrochloride is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
  • HY-19341
    Compound 401 Inhibitor 99.88%
    Compound 401 is a synthetic inhibitor of DNA-PK (IC50 = 0.28 μM) that also targets mTOR but not PI3K.