Signaling Pathway

PAK

PAK

Related Products

PDF File 0.23MB

PAK Inhibitors & Modulators (8)

Product Name Catalog No. Brief Description
APTO-253

HY-16291

APTO-253 is a novel small molecule with potent anti-tumor activity in cancer cells via induction of the gene that expresses the Krüppel-like factor 4 (KLF4) master transcription factor, leading to cell cycle inhibition and programmed cell death.

FRAX1036

HY-19538

FRAX1036 is a novel ATP-competitive small molecule inhibitor of group I p21-activated Kinases (PAKs).

FRAX486

HY-15542B

FRAX486 is a selective inhibitor of group I PAKs with IC50s of 8.25/39.5, /55.3 nM for PAK1/PAK2/PAK3 respectivelt; less potent for PAK4(IC50=779 nM).

FRAX597

HY-15542A

FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM).

G-5555

HY-19635

G-5555 is a selective PAK1 Inhibitor (Ki=3.7 nM).

IPA-3

HY-15663

IPA-3 is a selective non-ATP competitive PAK1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).

PAK4-IN-1

HY-12793

PAK4-IN-1 is an inhibitor of p21-activated kinases (PAKs), with IC50 of  ≤100 nM in MTT assay.

PF-3758309

HY-13007

PF-3758309 is a inhbitor of PAKs with IC50 of 1.3 nM for PAK4; inhbits tumor growth in HCT116, A549, M24met and other xenograft tumor models.