PAK4-IN-3
PAK4-IN-3(compound 27e) is aPAK4inhibitor, with theIC50of 10 nM.PAK4-IN-3shows antiproliferative activity against A549 cells with anIC50value of 0.61μM, and inducesapoptosisof A549 cells in a concentration-dependent manner and blocked the cell cycle at phase G0/G1.
For research use only. We do not sell to patients.
- Formula: C21H22ClN7O
- Molecular Weight:423.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
10 nM(PAK4)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.61 μM
Compound: 27e
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Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by CCK8 assay
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[PMID: 37864885] |
| HEK-293T | IC50 |
>10 μM
Compound: 27e
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Antiproliferative activity against HEK293T cells assessed as inhibition of cell growth incubated for 24 hrs by CCK8 assay
Antiproliferative activity against HEK293T cells assessed as inhibition of cell growth incubated for 24 hrs by CCK8 assay
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[PMID: 37864885] |
Chemical Information
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Molecular Weight 423.90
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Formula C21H22ClN7O
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SMILES
N[C@H](C(C)C)CNC(C1=NC2=CC=C(C=C2C(NC3=NNC4=C3C=CC=C4)=N1)Cl)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PAK4-IN-3 Related Classifications
HY-156453 Related Classifications
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