1. Recombinant Proteins
  2. Ubiquitin Related Proteins
  3. Ubiquitin Enzymes
  4. E2 Enzymes

Ubiquitin (Ub) or ubiquitin-like proteins (UBLs) carboxyl termini are attached to other proteins, or in some cases lipids, generally through E1-E2-E3 multienzyme cascades. Ubiquitin-conjugating enzymes (E2s) are responsible for transferring Ub/UBLs to substrate proteins and often function with a single or limited number of E3 ligases, although in some cases no E3 is required. Members of the family of ubiquitin-conjugating enzymes (E2s) are characterized by the presence of a highly conserved ∼150 amino acid residues ubiquitin-conjugating catalytic (UBC) fold. The UBC domains are ~35% conserved among different family members and provide a binding platform for E1s, E3s, and the activated Ub/UBL. Within this domain, a catalytic cysteine is embedded that accepts the activated ATP-activated Ub/UBLs via a covalently thioester bond, prior to interaction with E3 ligases and subsequent substrate conjugation. The majority of Ub/UBLs use particular E2s for conjugation, but in some cases E2s are shared, such as between the ubiquitin and ISG15-conjugation pathways.

Cat. No. Product Name / Synonyms Species Source
  • HY-P71016
    UBE2C Protein, Human (His)

    Ubiquitin-Conjugating Enzyme E2 C; UbcH10; Ubiquitin Carrier Protein C; Ubiquitin-Protein Ligase C; UBE2C; UBCH10

    Human E. coli
  • HY-P71398
    UBE2B Protein, Human (HEK293, His)

    Ubiquitin-Conjugating Enzyme E2 B; RAD6 Homolog B; HR6B; hHR6B; Ubiquitin Carrier Protein B; Ubiquitin-Conjugating Enzyme E2-17 kDa; Ubiquitin-Protein Ligase B; UBE2B; RAD6B

    Human HEK293
  • HY-P7617
    ATG3 Protein, Human

    rHuATG3; Ubiquitin-like-conjugating enzyme ATG3; Autophagy-related protein 3; APG3-like; ATG3; APG3; APG3L

    Human E. coli
    ATG3 Protein, Human is a recombinant human Ubiquitin-like-conjugating Enzyme ATG3 expressed in E. coli. ATG3, the E2 ubiquitin-conjugating enzyme for the LC3 lipidation process, is essential for autophagy.
  • HY-P71399
    UBE2D1 Protein, Human (GST)

    Ubiquitin-conjugating enzyme E2 D1; Stimulator of Fe transport; SFT; UBC4/5 homolog; UbcH5; Ubiquitin carrier protein D1; Ubiquitin-conjugating enzyme E2(17)KB 1; Ubiquitin-conjugating enzyme E2-17 kDa 1; Ubiquitin-protein ligase D1; SFT; UBC5A; UBCH5; UBCH5A

    Human E. coli
  • HY-P70998
    UBE2D3 Protein, Human

    Ubiquitin-conjugating enzyme E2 D3; Ubiquitin carrier protein D3; Ubiquitin-conjugating enzyme E2(17)KB 3; Ubiquitin-conjugating enzyme E2-17 kDa 3; Ubiquitin-protein ligase D3; UBE2D3 and UBCH5C.

    Human E. coli
  • HY-P71020
    UBE2L6 Protein, Human (His)

    Ubiquitin/ISG15-Conjugating Enzyme E2 L6; Retinoic Acid-Induced Gene B Protein; RIG-B; UbcH8; Ubiquitin Carrier Protein L6; Ubiquitin-Protein Ligase L6; UBE2L6; UBCH8

    Human E. coli
  • HY-P71397
    UBE2A Protein, Human (GST-His)

    Ubiquitin-Conjugating Enzyme E2 A; RAD6 Homolog A; HR6A; hHR6A; Ubiquitin Carrier Protein A; Ubiquitin-Protein Ligase A; UBE2A; RAD6A

    Human E. coli
  • HY-P71400
    UBE2D4 Protein, Human (GST)

    Ubiquitin-Conjugating Enzyme E2 D4; HBUCE1; Ubiquitin Carrier Protein D4; Ubiquitin-Protein Ligase D4; UBE2D4; UBCH5D

    Human E. coli
  • HY-P71401
    UBE2G2 Protein, Human (GST)

    Ubiquitin-Conjugating Enzyme E2 G2; Ubiquitin Carrier Protein G2; Ubiquitin-Protein Ligase G2; UBE2G2

    Human E. coli
  • HY-P71402
    UBE2H Protein, Human (GST)

    Ubiquitin-Conjugating Enzyme E2 H; UbcH2; Ubiquitin Carrier Protein H; Ubiquitin-Conjugating Enzyme E2-20K; Ubiquitin-Protein Ligase H; UBE2H

    Human E. coli
  • HY-P71403
    UBE2I Protein, Human (GST)

    SUMO-Conjugating Enzyme UBC9; SUMO-Protein Ligase; Ubiquitin Carrier Protein 9; Ubiquitin Carrier Protein I; Ubiquitin-Conjugating Enzyme E2 I; Ubiquitin-Protein Ligase I; p18; UBE2I; UBC9; UBCE9

    Human E. coli
  • HY-P71404
    UBE2J2 Protein, Human (GST)

    Ubiquitin-Conjugating Enzyme E2 J2; Non-Canonical Ubiquitin-Conjugating Enzyme 2; NCUBE-2; UBE2J2; NCUBE2

    Human E. coli
  • HY-P71405
    UBE2K Protein, Human (GST)

    Ubiquitin-Conjugating Enzyme E2 K; Huntingtin-Interacting Protein 2; HIP-2; Ubiquitin Carrier Protein; Ubiquitin-Conjugating Enzyme E2-25 kDa; Ubiquitin-Conjugating Enzyme E2(25K); Ubiquitin-Conjugating Enzyme E2-25K; Ubiquitin-Protein Ligase; UBE2K; HIP2; LIG

    Human E. coli
  • HY-P71406
    UBE2M Protein, Human

    NEDD8-conjugating enzyme Ubc12; NEDD8 carrier protein; NEDD8 protein ligase; Ubiquitin-conjugating enzyme E2 M; UBC12; UBE2M;

    Human E. coli
  • HY-P71407
    UBE2R2 Protein, Human (His)

    Ubiquitin-Conjugating Enzyme E2 R2; Ubiquitin Carrier Protein R2; Ubiquitin-Conjugating Enzyme E2-CDC34B; Ubiquitin-Protein Ligase R2; UBE2R2; CDC34B; UBC3B

    Human E. coli
  • HY-P71408
    UBE2S Protein, Human (GST)

    Ubiquitin-Conjugating Enzyme E2 S; E2-EPF; Ubiquitin Carrier Protein S; Ubiquitin-Conjugating Enzyme E2-24 kDa; Ubiquitin-Conjugating Enzyme E2-EPF5; Ubiquitin-Protein Ligase S; UBE2S; E2EPF

    Human E. coli
  • HY-P71409
    UBE2T Protein, Human (His)

    Ubiquitin-Conjugating Enzyme E2 T; Cell Proliferation-Inducing Gene 50 Protein; Ubiquitin Carrier Protein T; Ubiquitin-Protein Ligase T; UBE2T

    Human E. coli
  • HY-P71410
    UBE2V1 Protein, Human (His)

    Ubiquitin-Conjugating Enzyme E2 Variant 1; UEV-1; CROC-1; TRAF6-Regulated IKK Activator 1 Beta Uev1A; UBE2V1; CROC1; UBE2V; UEV1; P/OKcl.19

    Human E. coli
  • HY-P71411
    UBE2V2 Protein, Human (His)

    Ubiquitin-Conjugating Enzyme E2 Variant 2; DDVit 1; Enterocyte Differentiation-Associated Factor 1; EDAF-1; Enterocyte Differentiation-Promoting Factor 1; EDPF-1; MMS2 Homolog; Vitamin D3-Inducible Protein; UBE2V2; MMS2; UEV2

    Human E. coli
  • HY-P71412
    UBE2Z Protein, Human (His)

    Ubiquitin-Conjugating Enzyme E2 Z; Uba6-Specific E2 Conjugating Enzyme 1; Use1; Ubiquitin Carrier Protein Z; Ubiquitin-Protein Ligase Z; UBE2Z; HOYS7

    Human E. coli
Cat. No. Product Name Effect Purity