E2 Enzymes
Ubiquitin (Ub) or ubiquitin-like proteins (UBLs) carboxyl termini are attached to other proteins, or in some cases lipids, generally through E1-E2-E3 multienzyme cascades. Ubiquitin-conjugating enzymes (E2s) are responsible for transferring Ub/UBLs to substrate proteins and often function with a single or limited number of E3 ligases, although in some cases no E3 is required. Members of the family of ubiquitin-conjugating enzymes (E2s) are characterized by the presence of a highly conserved ∼150 amino acid residues ubiquitin-conjugating catalytic (UBC) fold. The UBC domains are ~35% conserved among different family members and provide a binding platform for E1s, E3s, and the activated Ub/UBL. Within this domain, a catalytic cysteine is embedded that accepts the activated ATP-activated Ub/UBLs via a covalently thioester bond, prior to interaction with E3 ligases and subsequent substrate conjugation. The majority of Ub/UBLs use particular E2s for conjugation, but in some cases E2s are shared, such as between the ubiquitin and ISG15-conjugation pathways.
- Ubiquitin Conjugating Enzyme E2 V2 (4)
- Ubiquitin-Conjugating Enzyme E2 E1 (2)
- Ubiquitin Conjugating Enzyme E2 L3 (UBE2L3) (2)
- Ubiquitin-Conjugating Enzyme E2 A (1)
- Ubiquitin Conjugating Enzyme E2 B (1)
- Ubiquitin-Conjugating Enzyme E2 D1 (1)
- UBE2D2 (1)
- Ubiquitin-Conjugating Enzyme E2 D3 (1)
- UBE2D4 (1)
- Ubiquitin Conjugating Enzyme E2 G1 (1)
- Ubiquitin Conjugating Enzyme E2 G2 (1)
- Ubiquitin-Conjugating Enzyme E2 H (1)
- Ubiquitin Conjugating Enzyme E2 I (1)
- Ubiquitin Conjugating Enzyme E2 J2 (1)
- Ubiquitin Conjugating Enzyme E2 L6 (1)
- Ubiquitin-Conjugating Enzyme E2 K (1)
- Ubiquitin Conjugating Enzyme E2 M (1)
- Ubiquitin Conjugating Enzyme E2 R2 (1)
- Ubiquitin conjugating enzyme E2 S (1)
- Ubiquitin-Conjugating Enzyme E2 T (1)
- UEV-1 (1)
- Ubiquitin-conjugating enzyme E2 W (1)
- Ubiquitin-Conjugating Enzyme E2 Z (1)
- Autophagy-Related Protein 10 (ATG10) (1)
- Autophagy-Related Protein 3 (ATG3) (1)
- Ubiquitin-conjugating enzyme E2 R1 (UBE2R1) (1)
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E2 Enzymes Recombinant Proteins (34)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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- 2
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
