CDNF/MANF family
Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) form a new neurotrophic factors family (NTFs) of evolutionarily conserved and may not act as classical, target-derived neurotrophic factors (NTFs) that are solely secreted proteins. CDNF is a vertebrate specific paralogue of MANF. CDNF/MANF are mostly intracellular and localize to the endoplasmic reticulum (ER) under normal conditions and protect cells from ER stress, and regulate the unfolded protein response via interacting with chaperons, and CDNF dissolves intracellular α-synuclein aggregates. In animal models of Parkinson's disease (PD), CDNF protects and repairs dopamine (DA) neurons, regulates ER stress, and improves motor function more efficiently than other NTFs.
-
CDNF/MANF family Recombinant Proteins (9)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
