1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Mps1

Mps1

Monopolar spindle 1 (Mps1), also known as TTK, is a serine threonine kinase, which ensures proper biorientation of sister chromatids on the mitotic spindle by the activation of the spindle assembly checkpoint (SAC). Mps1 has been shown to function as the key kinase that activates the spindle assembly checkpoint (SAC) to secure proper distribution of chromosomes to daughter cells.

Mps1 is a dual specificity protein kinase that is essential for the bipolar attachment of chromosomes to the mitotic spindle and for maintaining the spindle assembly checkpoint until all chromosomes are properly attached. Mps1 is expressed at high levels during mitosis and is abundantly expressed in cancer cells. Disruption of Mps1 function induces aneuploidy and cell death.

Mps1 Related Products (10):

Cat. No. Product Name Effect Purity
  • HY-101340
    CFI-402257 Inhibitor 99.52%
    CFI-402257 is a highly selective and orally bioavailable TTK and Mps1 inhibitor with Kis of 0.1 and 0.09 nM, respectively.
  • HY-12859
    BAY1217389 Inhibitor >98.0%
    BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM.
  • HY-12858
    BAY 1161909 Inhibitor >98.0%
    BAY 1161909 is a potent Mps1 inhibitor, with an IC50 of < 1 nM.
  • HY-13298
    Mps1-IN-1 Inhibitor 99.66%
    Mps1-IN-1 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 367 nM and 27 nM.
  • HY-12382
    NMS-P715 Inhibitor >99.0%
    NMS-P715 is a selective, ATP-competitive inhibitor of MPS1, with an IC50 of 182 nM.
  • HY-14710
    AZ3146 Inhibitor 99.64%
    AZ3146 is a reasonably potent and selective Mps1 inhibitor with IC50 of 35 nM for Mps1Cat.
  • HY-12660
    MPI-0479605 Inhibitor 99.77%
    MPI-0479605 is a potent and selective ATP-competitive inhibitor of Mps1, with an IC50 of 1.8 nM.
  • HY-13994
    Mps1-IN-2 Inhibitor 98.06%
    Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC50 and a Kd of 145 nM and 12 nM for Mps1 and a Kd of 61 nM for Plk1.
  • HY-14712
    NMS-P715 analog Inhibitor
    NMS-P715 analog is an inhibitor of MPS1, with an IC50 of 84 nM.
  • HY-12401
    Mps1-IN-3 Inhibitor
    Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC50 of 50 nM.
Isoform Specific Products

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