1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Mps1

Mps1

Monopolar spindle 1 (Mps1), also known as TTK, is a serine threonine kinase, which ensures proper biorientation of sister chromatids on the mitotic spindle by the activation of the spindle assembly checkpoint (SAC). Mps1 has been shown to function as the key kinase that activates the spindle assembly checkpoint (SAC) to secure proper distribution of chromosomes to daughter cells.

Mps1 is a dual specificity protein kinase that is essential for the bipolar attachment of chromosomes to the mitotic spindle and for maintaining the spindle assembly checkpoint until all chromosomes are properly attached. Mps1 is expressed at high levels during mitosis and is abundantly expressed in cancer cells. Disruption of Mps1 function induces aneuploidy and cell death.

Mps1 Related Products (10):

Cat. No. Product Name Effect Purity
  • HY-14710
    AZ3146 Inhibitor 99.64%
    AZ3146 is a reasonably potent and selective Mps1 inhibitor with IC50 of 35 nM for Mps1Cat.
  • HY-13298
    Mps1-IN-1 Inhibitor 99.89%
    Mps1-IN-1 is a highly potent and selectibe Mpsl inhibitor with IC50 of 367 nM; >1000-fold selectivity relative to the 352 member kinase panel with the major exceptions of Alk and Ltk.
  • HY-12858
    BAY 1161909 Inhibitor
    BAY 1161909 inhibits Mps1 kinase activity with IC50 of < 1 nM when assay with 10 μM ATP, with IC50 of < 1.9 nM when assay with 2 mM ATP.
  • HY-12859
    BAY1217389 Inhibitor >98.0%
    BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM.
  • HY-12660
    MPI-0479605 Inhibitor
    MPI-0479605 is a potent, ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, > 40-fold selectivity over other kinases.
  • HY-101340
    CFI-402257 Inhibitor
    CFI-402257 is a highly selective and orally bioavailable TTK and Mps1 inhibitor with Kis of 0.1 and 0.09 nM, respectively.
  • HY-12382
    NMS-P715 Inhibitor 99.46%
    NMS-P715 is the first selective, ATP-competitive and orally bioavailable MPS1 small-molecule inhibitor(IC50=8 nM); selectively reduces cancer cell proliferation, leaving normal cells almost unaffected.
  • HY-13994
    Mps1-IN-2 Inhibitor
    Mps1-IN-2 is a potent Mps1 kianse inhibitor with IC50 value of 145 nM.
  • HY-14712
    NMS-P715 analog Inhibitor
    NMS-P715 analog is the analog of NMS-P715, which is the first selective, ATP-competitive and orally bioavailable MPS1 small-molecule inhibitor(IC50=8 nM); selectively reduces cancer cell proliferation, leaving normal cells almost unaffected.
  • HY-12401
    Mps1-IN-3 Inhibitor
    Mps1-IN-3 is a selective and highly potent MPS1 kinase inhibitor with an IC50 of 50 nM.