Signaling Pathway

Mps1

Mps1

Related Products

PDF File 0.24MB

Mps1 Inhibitors & Modulators (9)

Product Name Catalog No. Brief Description
AZ3146

HY-14710

AZ3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM); less potent to FAK, JNK1, JNK2, and Kit.

BAY 1161909

HY-12858

BAY 1161909 inhibits Mps1 kinase activity with IC50 of < 1 nM when assay with 10 μM ATP, with IC50 of < 1.9 nM when assay with 2 mM ATP.

BAY1217389

HY-12859

BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM.

MPI-0479605

HY-12660

MPI-0479605 is a potent, ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, > 40-fold selectivity over other kinases.

Mps1-IN-1

HY-13298

Mps1-IN-1 is a highly potent and selectibe Mpsl inhibitor with IC50 of 367 nM; >1000-fold selectivity relative to the 352 member kinase panel with the major exceptions of Alk and Ltk.

Mps1-IN-2

HY-13994

Mps1-IN-2 is a potent Mps1 kianse inhibitor with IC50 value of 145 nM.

Mps1-IN-3

HY-12401

Mps1-IN-3 is a selective and highly potent MPS1  kinase inhibitor with an IC50 of 50 nM.

NMS-P715

HY-12382

NMS-P715 is the first selective, ATP-competitive and orally bioavailable MPS1 small-molecule inhibitor(IC50=8 nM); selectively reduces cancer cell proliferation, leaving normal cells almost unaffected.

NMS-P715 analog

HY-14712

NMS-P715 analog is the analog of NMS-P715, which is the first selective, ATP-competitive and orally bioavailable MPS1 small-molecule inhibitor(IC50=8 nM); selectively reduces cancer cell proliferation, leaving normal cells almost unaffected.