Signaling Pathway

Notch

Notch

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The notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms. Notch is present in all metazoans, and mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The notch receptor is a single-pass transmembrane receptor protein. It is a hetero-oligomer composed of a large extracellular portion, which associates in a calcium-dependent, non-covalent interaction with a smaller piece of the notch protein composed of a short extracellular region, a single transmembrane-pass, and a small intracellular region. Notch signaling promotes proliferative signaling during neurogenesis, and its activity is inhibited by Numb to promote neural differentiation. The notch signaling pathway is important for cell-cell communication, which involves gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life.

Notch Inhibitors & Modulators (8)

Product Name Catalog No. Brief Description
BMS-983970

HY-12419

BMS-983970 is an oral pan-Notch inhibitor for the treatment of cancer.

FLI-06

HY-15860

FLI-06 is a novel potent and selective small molecule intercepting Notch signaling and the early secretory pathway (EC50 ~2.3 μM), identified by using automated microscopy to monitor the trafficking and processing of a ligand-independent Notch-GFP fusion reporter.

IMR-1

HY-100431

IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L.

IMR-1A

HY-100431A

IMR-1A is the metabolite of IMR-1.

LY3039478

HY-12449

LY3039478 is a novel and potent Notch inhibitor.

Psoralidin

HY-N0232

Psoralidin, a natural furanocoumarin, is isolated from Psoralea corylifolia L.

Tangeretin

HY-N0133

Tangeretin, a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and was also selected as a Notch-1 inhibitor.

Z-Ile-Leu-aldehyde

HY-12465

Z-Ile-Leu-aldehyde(Z-IL-CHO; GSI-XII) is a potent gamma-Secretase inhibitor; Notch signaling inhibitor.