1. Neuronal Signaling
    Stem Cell/Wnt
    Apoptosis
  2. Notch
    Apoptosis
  3. Bruceine D

Bruceine D 

Cat. No.: HY-N3014 Purity: 95.75%
Handling Instructions

Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity.

For research use only. We do not sell to patients.

Bruceine D Chemical Structure

Bruceine D Chemical Structure

CAS No. : 21499-66-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 143 In-stock
Estimated Time of Arrival: December 31
1 mg USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 158 In-stock
Estimated Time of Arrival: December 31
10 mg USD 269 In-stock
Estimated Time of Arrival: December 31
20 mg USD 457 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity[1][2].

IC50 & Target

Notch[1]

In Vitro

Bruceine D inhibits the cell viability of H460 and A549 cells in a dose-dependent manner with IC50 values of 0.5 and 0.6 μM, respectively, at 48 h of treatment[1].
Bruceine D (0.125-1.0 μM) dose-dependently promotes chromatin condensation, Annexin V-positive cell population and caspase-dependent apoptosis in H460 and A549 cells[1].

Molecular Weight

410.42

Formula

C₂₀H₂₆O₉

CAS No.

21499-66-1

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
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