TIM-3
T cell immunoglobulin and mucin-domain containing-3 (TIM-3)，also called HAVCR2, is a co-inhibitory receptor that belongs to the TIM gene family. TIM-3 is a type I trans-membrane protein that was originally discovered as a cell surface marker specific to IFN-γ producing Th1 and Tc1 cells. Hitherto, TIM-3 is detected in different types of immune cells, including T cells, regulatory T cells (Tregs), dendritic cells (DCs), B cells, macrophages, nature killer (NK) cells, and mast cells. Thus far, four distinct ligands for Tim-3 have been reported: galectin-9 (Gal-9), carcinoembryonic antigen cell adhesion molecule 1 (CEACAM-1), high-mobility group protein B1 (HMGB1), and phosphatidylserine (PtdSer). TIM-3 has been shown to mediate immune tolerance and is also associated with immune exhaustion.
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TIM-3 Recombinant Proteins (14)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
