1. Signaling Pathways
  2. Immunology/Inflammation
  3. Galectin

Galectin

Galectins comprise a family of soluble β-galactoside binding proteins, which regulate key biological processes including cell growth, differentiation, apoptosis, and immune responses.

Sixteen galectin genes have been identified in animal kingdoms, 12 of which are expressed in humans. Galectins are usually classified into three groups based on their structure: (i) prototypical galectins (galectin-1 (Gal1), Gal2, Gal5, Gal7, Gal10, Gal11, Gal 13, Gal14, and Gal15), characterized by a single CRD, which can act as monomers or form homodimers; (ii) the chimeric galectin Gal3 (the only member of this class), with a single CRD and a large amino-terminal domain that facilitates the formation of oligomers; (iii) the tandem repeat galectins, with two CRDs that are linked through a small peptide domain; this group includes Gal4, Gal6, Gal8, Gal9, and Gal12. Recently, Galectins have been implicated as major therapeutic determinants that confer sensitivity or resistance to a wide range of anticancer modalities including chemotherapy, radiotherapy, targeted therapies, antiangiogenic therapies, and immunotherapies.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-114409
    GB1107
    Inhibitor 99.90%
    GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model.
    GB1107
  • HY-19756
    OTX008
    Inhibitor 99.09%
    OTX008 is a selective inhibitor of galectin-1.
    OTX008
  • HY-147041
    Selvigaltin
    Inhibitor 98.72%
    Selvigaltin (GB1211) is an orally available galectin-3 (Gal-3) inhibitor.
    Selvigaltin
  • HY-19940
    Olitigaltin
    Inhibitor 99.22%
    TD139 is an inhaled galectin-3 inhibitor with a Kd of 14 nM.
    Olitigaltin
  • HY-130208
    Thiodigalactoside
    Inhibitor ≥99.0%
    Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats.
    Thiodigalactoside
  • HY-157821
    Galectin-4-IN-3
    Inhibitor
    Galectin-4-IN-3 (Compound 11) is a Galectin 4C inhibitor, with a Kd of 160 μM.
    Galectin-4-IN-3
  • HY-155192
    Galectin-3/galectin-8-IN-2
    Inhibitor
    Galectin-3/galectin-8-IN-2 (Compound 57) is a dual Galectin-3 and galectin-8 C-terminal domain inhibitor, with Kd values of 12.8 μM and 2.06 μM respectively. Galectin-3/galectin-8-IN-2 inhibits the MRC-5 lung fibroblast cells migration. Galectin-3/galectin-8-IN-2 can be used for research of cancer and tissue fibrosis.
    Galectin-3/galectin-8-IN-2
  • HY-W150340
    β-Lactose
    Inhibitor ≥98.0%
    β-Lactose is a disaccharide commonly found in milk and dairy products. It consists of two monosaccharides, glucose and galactose, linked by β-glycosidic bonds. β-Lactose has various applications in the food industry, especially as a sweetener and bulking agent. Furthermore, it can be used as a substrate for enzymes involved in lactose metabolism and as a model compound for studying carbohydrate-protein interactions.
    β-Lactose
  • HY-P1592A
    G3-C12 TFA
    99.44%
    G3-C12 (TFA) is a galectin-3 binding peptide, with Kd of 88 nM, and shows anticancer activity.
    G3-C12 TFA
  • HY-114440
    Belapectin
    Inhibitor
    Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Ki of 2.8 μM.
    Belapectin
  • HY-150235
    Galectin-8N-IN-1
    Inhibitor 98.09%
    Galectin-8N-IN-1 (compound 19a) is a potent and selective galectin-8N inhibitor with a Kd value of 1.8 μM. Galectin-8N-IN-1 is a galectin-8N ligand. Galectin-8N-IN-1 can be used in research of immune system.
    Galectin-8N-IN-1
  • HY-146808
    Galectin-3 antagonist 1
    Antagonist 99.77%
    Galectin-3 antagonist 1 (compound 15) is a potent and selective Galectin-3 (Gal-3) antagonist with Kd value of 5.3 μM. Meanwhile, Galectin-3 antagonist 1 binds to various Galectin with Kd values of 250 μM (Gal-4N), 18 μM (Gal-4C), 450 μM (Gal-8C), respectively.
    Galectin-3 antagonist 1
  • HY-P1592
    G3-C12
    99.44%
    G3-C12 is a galectin-3 binding peptide, with Kd of 88 nM, and shows anticancer activity.
    G3-C12
  • HY-157822
    Galectin-8-IN-2
    Inhibitor
    Galectin-8-IN-2 (Compound 10) is a galectin-8N inhibitor.
    Galectin-8-IN-2
  • HY-155191
    Galectin-3/galectin-8-IN-1
    Inhibitor
    Galectin-3/galectin-8-IN-1 (Compound 53) is a dual Galectin-3 and galectin-8 C-terminal domain inhibitor, with Kd values of 4.12 μM and 6.04 μM respectively. Galectin-3/galectin-8-IN-1 inhibits the MRC-5 lung fibroblast cells migration. Galectin-3/galectin-8-IN-1 can be used for research of cancer and tissue fibrosis.
    Galectin-3/galectin-8-IN-1
  • HY-157824
    6Lac[6]Met
    Inhibitor
    6Lac[6]Met is a galectin 4 inhibitor with an IC50 value 5 μM.
    6Lac[6]Met
  • HY-139831
    Galectin-8-IN-1
    Galectin-8-IN-1 is a selective ligand for the galectin-8 N-terminal domain (galectin-8N), with a Kd of 48 μM and 15-fold selectivity over galectin-3 and even better selectivity over the other mammalian galectins.
    Galectin-8-IN-1
  • HY-147865
    Apoptosis inducer 8
    Inhibitor
    Apoptosis inducer 8 (Compound 7c) is a galectin-1 (gal-1) mediated apoptosis-inducing agent against global major leading lung cancer burden. Apoptosis inducer 8 significantly reduced the gal-1 protein level. Apoptosis inducer 8 is also a PET imaging agent.
    Apoptosis inducer 8
  • HY-144313
    Galectin-3-IN-2
    Inhibitor
    Galectin-3-IN-2 (Compound 9) is a potent multivalent inhibitor of galectin-3 (Gal-3; IC50=8.3 μM). Galectin-3 participates in many cancer-related metabolic processes.
    Galectin-3-IN-2
  • HY-146809
    Galectin-3 antagonist 2
    Galectin-3 is a β Galactoside specific carbohydrate recognition protein (lectin) has the ability to promote the migration of B cell precursor acute lymphoblastic leukemia (BCP-ALL) cells and withstand drug research.
    Galectin-3 antagonist 2
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