Galectin

Galectin Related Products (20):

By Effects:	Inhibitors (14) Antagonist (1) Degrader (1) Ligands (2)

Cat. No.	Product Name	Effect	Purity

HY-19940

Olitigaltin	Inhibitor	99.74%
TD139 is a synthetic galectin-3 inhibitor. TD139 has high affinity for galectin-3 with a K_d of 68 nM, a K_d of 0.22 μM for galectin-1, and a K_d of 38 μM for galectin-7.

HY-130208

Thiodigalactoside	Inhibitor	99.97%
Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with K_d values of 24 μM, 49 μM for GAL1 and GAL3, respectively. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats.

HY-W150340

β-Lactose	Inhibitor	99.31%
β-Lactose is a disaccharide commonly found in milk and dairy products. It consists of two monosaccharides, glucose and galactose, linked by β-glycosidic bonds. β-Lactose has various applications in the food industry, especially as a sweetener and bulking agent. Furthermore, it can be used as a substrate for enzymes involved in lactose metabolism and as a model compound for studying carbohydrate-protein interactions.

HY-N9497

Galactinol	Ligand	99.92%
Galactinol is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot.

HY-P991228

LYT-200	Inhibitor	99.16%
LYT-200 is a humanized monoclonal antibody against galectin-9 (Galectin-9). LYT-200 binds to galectin-9 expressed on the surface of hematologic malignant cells, inhibits pro-leukemic functions and induces cell death. LYT-200 can be used in research related to hematologic malignancies.

HY-P992257

Anti-LGALS3BP Antibody
Anti-LGALS3BP Antibody is a monoclonal antibody targeting LGALS3BP. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LGALS3BP Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-135258

Galactinol dihydrate	Ligand	98.0%
Galactinol dihydrate is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol dihydrate not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol dihydrate has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol dihydrate can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot.

HY-P990198

Anti-Mouse/Human Mac-2/Galectin-3 Antibody (TIB-166)	Inhibitor
Anti-Mouse/Human Mac-2/Galectin-3 Antibody (TIB-166) is a rat-derived anti-mouse/human Mac-2/Galectin-3 IgG2a monoclonal antibody. Anti-Mouse/Human Mac-2/Galectin-3 Antibody (TIB-166) significantly inhibits IL-6 expression (inhibition rates 34.7% and 55.3%). Anti-Mouse/Human Mac-2/Galectin-3 Antibody (TIB-166) is often used for immunoprecipitation, western blot, immunofluorescence, and flow cytometry.

HY-W340234

4,5-Dibromo-2-pyrrolic acid		99.34%
4,5-Dibromo-2-pyrrolic acid (compound 2) is an immunosuppressive compound. 4,5-Dibromo-2-pyrrolic acid suppresses the proliferative response of splenocytes to suboptimal concentrations of the mitogen, concanavalin A (Con A).

HY-170510

GB2095	Inhibitor	98.92%
GB2095 is an orally active and selective galectin-3 inhibitor. GB2095 shows superior selectivity for both human (K_D = 0.036 μM) and mouse galectin-3 (K_D = 0.35 μM) over other galectins (such as h-Gal-1/4N/4C/8N/8C/9N/9C and m-galectin-1). GB2095 inhibits tumor growth in syngeneic mouse models of breast and melanoma cancers. GB2095 can be used for breast and melanoma cancer research.

HY-P10010

DB21, Galectin-1 Antagonist	Inhibitor
DB21, Galectin-1 Antagonist is a dibenzofuran conjugated peptidomimetic that acts as an allosteric inhibitor of galectin-1 (GAL1)binding to cell surface glycans. DB21, Galectin-1 Antagonis increases inhibition of angiogenesis and tumour growth in melanoma, lung adenocarcinoma and ovarian cancer models.

HY-126854R

N-Acetyllactosamine (Standard)	Inhibitor
N-Acetyllactosamine (Standard) is the analytical standard of N-Acetyllactosamine. This product is intended for research and analytical applications. N-Acetyllactosamine (N-Acetyl-D-lactosamine), a nitrogen-containing disaccharide, is a galectin-3 inhibitor, which is an important component of various oligosaccharides such as glycoproteins and sialyl Lewis X. N-Acetyllactosamine can be used as the starting material for the synthesis of various oligosaccharides. N-Acetyllactosamine has prebiotic effects[1][2][3][4].

HY-155192

Galectin-3/galectin-8-IN-2	Inhibitor
Galectin-3/galectin-8-IN-2 (Compound 57) is a dual Galectin-3 and galectin-8 C-terminal domain inhibitor, with K_d values of 12.8 μM and 2.06 μM respectively. Galectin-3/galectin-8-IN-2 inhibits the MRC-5 lung fibroblast cells migration. Galectin-3/galectin-8-IN-2 can be used for research of cancer and tissue fibrosis.

HY-157822

Galectin-8-IN-2	Inhibitor
Galectin-8-IN-2 (Compound 10) is a galectin-8N inhibitor.

HY-157820

Galectin-4-IN-2	Inhibitor
Galectin-4-IN-2 (compound 12) is an inhibitor of galectin 4C with a galectin dissociation constant of 1.6 mM.

HY-173235

Galectin-3-IN-6	Inhibitor
Galectin-3-IN-6 (Compound 12) is a human and murine galectin-3 (Gal-3) inhibitor, with an IC₅₀ of 12 nM against human galectin-3, an IC₅₀ of 12.6 nM against mutant murine galectin-3 (V160A), and a K_d of 13 nM for human galectin-3, as well as oral bioavailability. Galectin-3-IN-6 reduces the levels of liver fibrosis markers type I collagen and α-smooth muscle actin in mouse models of acute liver injury and fibrosis. Galectin-3-IN-6 can be used for the research of acute liver injury and fibrosis.

HY-123708

SNAP 398299	Antagonist
SNAP 398299 is a Gal3 receptor antagonist with potential anxiolytic and antidepressant effects. SNAP 398299 can partially reverse the neuropeptide Galanin-induced inhibition of dorsal raphe cell firing and the Galanin-induced hyperpolarizing current.

HY-163405

Galectin-3-IN-3	Inhibitor
Galectin-3-IN-3 (Compound 4) is an orally active and selective inhibitor of Gal-3, with IC₅₀ values of 11 nM and 84 nM against mGal-3 and hGal-3 respectively.

HY-176259

F3-PEG8-RiboTAC	Degrader
F3-PEG8-RiboTAC is a RiboTAC that can specifically degrade the mRNA of the oncogene LGALS1. F3-PEG8-RiboTAC can induce tumor cell apoptosis and inhibit invasion. F3-PEG8-RiboTAC has anti-tumor activity and can be used in the research of tumors such as leukemia and triple-negative breast cancer. (RNase L ligand (HY-177030); RNA binder (HY-177031); Linker (HY-W019798)).

HY-162789

Galectin-3-IN-5	Inhibitor
Galectin-3-IN-5 (Compound 20) is an orally active inhibitor of galectin-3 (Gal-3), with an IC₅₀ value of 9.2 nM against hGal-3.

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