51555-87-4
Chemical Structure
Thiodigalactoside
Synonym(s): TDG
- CAS No.: 51555-87-4
- Formula:C12H22O10S
- Molecular Weight:358.36
IUPAC Name: (2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-thiobis(2-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol)
InChIKey: SYKYBMOFPMXDRQ-ZFDCCPEWSA-N
SMILES: O[C@H]([C@H]1O)[C@@H](O[C@@H]([C@@H]1O)CO)S[C@@H]([C@@H]([C@H]2O)O)O[C@@H]([C@@H]2O)CO
Biological Activity: Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively[1]. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Thiodigalactoside | 99.92% | Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats. | ||||||||||||||||||||
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References
- [1]. Hilde van Hattum, et al. Tuning the Preference of Thiodigalactoside- And Lactosamine-Based Ligands to galectin-3 Over galectin-1. J Med Chem. 2013 Feb 14;56(3):1350-4. [Content Brief]
- [2]. Varun V Prabhu, et al. Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner. Cancer Res. 2015 Apr 1;75(7):1423-32. [Content Brief]
