Complement Factor H Related 5
Complement factor H-related protein 5 (CFHR5) is a nine-domain FHR family protein that binds C3b and C3d, heparin, and pentraxins, and is produced notably in the kidney as well as in liver. By interacting with deposited C3 fragments and glomerular basement-membrane ligands, CFHR5 modulates alternative-pathway activity on renal surfaces, and gain-of-function or hybrid CFHR5-factor H proteins cause C3 glomerulopathy, including a form endemic to Cyprus. It also associates with meningococcal surfaces. Recombinant CFHR5 is used to dissect glomerular complement regulation, C3b binding, and the pathogenesis of CFHR5 nephropathy. Like other FHR proteins, CFHR5 can form homo- and heterodimers within the family.
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Complement Factor H Related 5 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
