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Cat. No.: HY-L158

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Highly Selective Inhibitors Library

83 Cited Publications

Customer Review

Based on 83 publication(s) in Google Scholar

According to reports, most known kinase inhibitors exert their effects through competitive binding in highly conserved ATP pockets. Although genetic techniques such as RNA interference can inactivate specific genes, most kinases are multi domain proteins, each of which has an independent function. Highly selective inhibitors have higher efficiency than non-selective inhibitors, and the selectivity to the target is at least 100 times higher. Therefore, ensuring the validation of targets with the most selective inhibitors is crucial for a more thorough understanding of the pharmacology of the kinase field. The Highly Selective Inhibitors Library contains 6,265 compounds, covering multiple targets and subtypes, such as GPCR protein family, Ion channel, multiple kinases, etc. The Highly Selective Inhibitors Library is an effective tool for screening different phenotypes

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

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Description & Advantages
Product Details
- Formulation
- Layout
- Container
- Storage
- Shipping
Publications (83)
Documentation

Description & Advantages

• A unique collection of 6,265 highly selective inhibitors covering more than 1000 targets and isoforms.

• A useful tool for drug discovery.

• Target diverse, medicinally active and cell permeable.

• Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

• More detailed compound information with structure, IC50, and other chemical & biological data.

• High purity and quality validated by NMR and LC/MS.

Product Details

Formulation

A collection of 6,265 highly selective inhibitors supplied as pre-dissolved Solutions or Solid

Solution: 6,091 compounds supplied in 10 mM solution, 169 compounds supplied in 2 mM solution, 5 compounds supplied in 3 mg/mL solution.

Layout

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage

-80°C

Shipping

Blue ice or dry ice