2. Recombinant Proteins
  3. Immune Checkpoint Proteins
  4. Inhibitory Checkpoint Molecules
  5. PVRIG

PVRIG

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PVRIG (CD112R) is an inhibitory immune-checkpoint receptor that binds only to its ligand CD112 (Nectin-2) with high affinity on target cells suppressing lymphocyte cytotoxic function. CD112R is expressed in CD4+ and CD8+T cells, γδ T, NKT, and NK cells. CD112R interacts with CD112 competing with DNAM-1 but not with CD155 (PVR). It has been demonstrated that blocking the CD112-CD112R axis increases effector T-cell function in cancer, suggesting that the CD112-CD112R and CD155-TIGIT pathways could be non-redundant inhibitory signaling pathways.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P71247
    PVRIG Protein, Human (HEK293, Fc)

    C7orf15; CD112R; PVRIG; transmembrane protein PVRIG; C7orf15MGC138295; MGC104322; MGC138297; MGC2463

    		Human HEK293
    The PVRIG protein functions as a cell surface receptor for NECTIN2 and may serve as a co-inhibitory receptor capable of inhibiting T-cell receptor-mediated signaling. Upon interaction with NECTIN2, PVRIG inhibits T cell proliferation, suggesting its potential role in regulating immune responses. PVRIG Protein, Human (HEK293, Fc) is the recombinant human-derived PVRIG protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PVRIG Protein, Human (HEK293, Fc) is 131 a.a., with molecular weight of 45-50 kDa.
  • HY-P70466
    PVRIG Protein, Cynomolgus (HEK293, His)

    C7orf15; CD112R; PVRIG; transmembrane protein PVRIG; C7orf15MGC138295; MGC104322; MGC138297; MGC2463

    		Cynomolgus HEK293
    The PVRIG protein functions as a cell surface receptor for NECTIN2 and may serve as a co-inhibitory receptor capable of inhibiting T-cell receptor-mediated signaling. Upon interaction with NECTIN2, PVRIG inhibits T cell proliferation, suggesting its potential role in regulating immune responses. PVRIG Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived PVRIG protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PVRIG Protein, Cynomolgus (HEK293, His) is 131 a.a., with molecular weight of 20-30 kDa.
  • HY-P71248
    PVRIG Protein, Human (HEK293, mFc)

    C7orf15; CD112R; PVRIG; transmembrane protein PVRIG; C7orf15MGC138295; MGC104322; MGC138297; MGC2463

    		Human HEK293
    The PVRIG protein functions as a cell surface receptor for NECTIN2 and may serve as a co-inhibitory receptor capable of inhibiting T-cell receptor-mediated signaling. Upon interaction with NECTIN2, PVRIG inhibits T cell proliferation, suggesting its potential role in regulating immune responses. PVRIG Protein, Human (HEK293, mFc) is the recombinant human-derived PVRIG protein, expressed by HEK293 , with C-mFc labeled tag. The total length of PVRIG Protein, Human (HEK293, mFc) is 131 a.a., with molecular weight of 45-55 kDa.
  • HY-P700818
    PVRIG Protein, Mouse (Biotinylated, HEK293, Fc-Avi)

    C7orf15; CD112R; MGC104322; MGC138297; MGC2463; PVRIG; ALS2CR18; ALS2CR9; LPD; PREL-2; PREL2; RalGDS/AF-6; RMO1

    		Mouse HEK293
    PVRIG Protein, a member of the nectin and nectin-like family, is an immune checkpoint molecule with potential for development. PVRIG binds with high affinity to PVRL2 are inhibitory receptors on effector T cells, suppressing cytokine production and cytotoxic activity. PVRIG blocking antibodies significantly increased NK-cell cytotoxicity. PVRIG Protein, Mouse (Biotinylated, HEK293, Fc-Avi) is the recombinant mouse-derived PVRIG protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of PVRIG Protein, Mouse (Biotinylated, HEK293, Fc-Avi) is 131 a.a., with molecular weight of 55-65 kDa.
  • HY-P700819
    PVRIG Protein, Mouse (HEK293, Fc-Avi)

    C7orf15; CD112R; MGC104322; MGC138297; MGC2463; PVRIG; ALS2CR18; ALS2CR9; LPD; PREL-2; PREL2; RalGDS/AF-6; RMO1

    		Mouse HEK293
    PVRIG Protein, a member of the nectin and nectin-like family, is an immune checkpoint molecule with potential for development. PVRIG binds with high affinity to PVRL2 are inhibitory receptors on effector T cells, suppressing cytokine production and cytotoxic activity. PVRIG blocking antibodies significantly increased NK-cell cytotoxicity. PVRIG Protein, Mouse (HEK293, Fc-Avi) is the recombinant mouse-derived PVRIG protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of PVRIG Protein, Mouse (HEK293, Fc-Avi) is 131 a.a., with molecular weight of 53-63 kDa.
  • HY-P78343
    PVRIG Protein, Cynomolgus (HEK293, Fc)

    C7orf15; CD112R; MGC104322; MGC138297; MGC2463; PVRIG; ALS2CR18; ALS2CR9; LPD; PREL-2; PREL2; RalGDS/AF-6; RMO1

    		Cynomolgus HEK293
    The PVRIG protein functions as a cell surface receptor for NECTIN2 and may serve as a co-inhibitory receptor capable of inhibiting T-cell receptor-mediated signaling. Upon interaction with NECTIN2, PVRIG inhibits T cell proliferation, suggesting its potential role in regulating immune responses. PVRIG Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived PVRIG protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PVRIG Protein, Cynomolgus (HEK293, Fc) is 131 a.a., with molecular weight of 50-60 kDa.
  • HY-P70961
    PVRIG Protein, Mouse (HEK293, Fc)

    C7orf15; CD112R; PVRIG; transmembrane protein PVRIG; C7orf15MGC138295; MGC104322; MGC138297; MGC2463

    		Mouse HEK293
    PVRIG Protein, a member of the nectin and nectin-like family, is an immune checkpoint molecule with potential for development. PVRIG binds with high affinity to PVRL2 are inhibitory receptors on effector T cells, suppressing cytokine production and cytotoxic activity. PVRIG blocking antibodies significantly increased NK-cell cytotoxicity. PVRIG Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PVRIG protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PVRIG Protein, Mouse (HEK293, Fc) is 131 a.a., with molecular weight of 48-55 kDa.
  • HY-P72409
    PVRIG Protein, Human (Biotinylated, HEK293, Fc-Avi)

    C7orf15; CD112R; PVRIG; transmembrane protein PVRIG; C7orf15MGC138295; MGC104322; MGC138297; MGC2463

    		Human HEK293
    The PVRIG protein functions as a cell surface receptor for NECTIN2 and may serve as a co-inhibitory receptor capable of inhibiting T-cell receptor-mediated signaling. Upon interaction with NECTIN2, PVRIG inhibits T cell proliferation, suggesting its potential role in regulating immune responses. PVRIG Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived PVRIG protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of PVRIG Protein, Human (Biotinylated, HEK293, Fc-Avi) is 131 a.a., with molecular weight of 50-60 kDa.
Cat. No. Product Name Effect Purity