1. MAPK/ERK Pathway
  2. MAP3K

MAP3K

MAP3Ks (Mitogen-activated protein kinase kinase kinases), the top components of MAPK cascades, modulate many biological processes, such as growth, development and various environmental stresses. Based on the sequence of their kinase catalytic domain, MAP3Ks are classified into three groups: the MEKK-like, ZIK-like and Raf-like families. Raf-like MAP3Ks constitute largest MAP3K subfamily. Raf-like MAP3Ks play roles in response to biotic and abiotic stresses.

MAP3Ks often bind to both MAP4Ks and MAP2Ks in the same pathway. For example, MEKK1 (MAP3K1) binds to both the MAP4K NIK and the MAP2K MKK4, while NSY-1 (MAP3K) binds to the MAP2K SEK-1. MAP3Ks activates MAP2Ks by phosphorylation of a serine and/or threonine, and MAP2Ks activate MAPKs by dual phosphorylation of a Thr-X-Tyr motif.

MAP3K Isoform Specific Products:

  • MAP3K5/ASK1

  • MAP3K7/TAK1

MAP3K Related Products (6):

Cat. No. Product Name Effect Purity
  • HY-18938
    Selonsertib Inhibitor 98.04%
    Selonsertib is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3±0.07.
  • HY-103490
    Takinib Inhibitor 98.00%
    Takinib is a potent and selective TAK1 inhibitor with an IC50 of 9.5 nM.
  • HY-15434
    NG25 Inhibitor 99.45%
    NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.
  • HY-19566
    NQDI-1 Inhibitor 98.04%
    NQDI-1 inhibits apoptosis signal-regulating kinase 1 (ASK1) with a Ki of 500 nM and an IC50 of 3 μM.
  • HY-100844
    ASK1-IN-1 Inhibitor 99.33%
    ASK1-IN-1 is an apoptosis signal regulating kinase 1 (ASK1) inhibitor extracted from patent WO2016025474A1, Compound 4.
  • HY-12686
    5Z-7-Oxozeaenol Inhibitor >99.0%
    5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of 8 nM and 52 nM, respectively.
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.