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Cat. No.: HY-124865

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MAP3K14-IN-1

MAP3K14-IN-1 (Compound 173) is a MAP3K14 (NIK kinase) inhibitor with an IC₅₀ of 1.8 nM. MAP3K14-IN-1 inhibits the autophosphorylation of MAP3K14 kinase. MAP3K14-IN-1 reduces the level of phosphorylated IKKα in cancer cells. MAP3K14-IN-1 inhibits the proliferation of multiple myeloma cells. MAP3K14-IN-1 can be used in research related to multiple myeloma.

For research use only. We do not sell to patients.

CAS No.: 2113617-02-8
Formula: C₂₉H₃₁N₇O₂
Molecular Weight:509.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MAP3K14-IN-1 Chemical Structure

CAS No.: 2113617-02-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

NIK/MAP3K14

1.8 nM (IC₅₀)

IKKα

1.3 nM (IC₅₀)

All MAP3K Isoforms :

All IKK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
JJN-3	IC₅₀	29 nM Compound: 173	Antiproliferative activity against human JJN-3 cells after 96 hrs by CellTiter-Glo luminescence assay Antiproliferative activity against human JJN-3 cells after 96 hrs by CellTiter-Glo luminescence assay	[PMID: 28947934]
KMS-12-BM	IC₅₀	>10 μM Compound: 173	Antiproliferative activity against human KMS-12-BM cells after 96 hrs by CellTiter-Glo luminescence assay Antiproliferative activity against human KMS-12-BM cells after 96 hrs by CellTiter-Glo luminescence assay	[PMID: 28947934]

In Vitro

MAP3K14-IN-1 inhibits autophosphorylation of recombinant MAP3K14/NIK kinase in cell-free assays, with an IC₅₀ of 1.8 nM^[1].
MAP3K14-IN-1 inhibits the level of p-IKKα in L363 multiple myeloma cells, with an IC₅₀ of 1.3 nM^[1].
MAP3K14-IN-1 inhibits the proliferation of JJN-3 multiple myeloma cells with an IC₅₀ of 29 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2113617-02-8
Molecular Weight 509.61
Formula C₂₉H₃₁N₇O₂
SMILES

C(O)[C@]1(C)C=2C(=C(C#N)C=C(C2)C3=NC(NC4=CC(C#N)=C(CCN5CCOCC5)C=C4C)=NC=C3)NC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kargbo RB. New Substituted Cyanoindoline Derivatives as MAP3K14 Kinase Inhibitors for the Treatment of Cancer and Autoimmune Disorders. ACS Med Chem Lett. 2017 Aug 17;8(9):908-910. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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MAP3K14-IN-1

All MAP3K Isoforms

All IKK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

MAP3K14-IN-1 Related Classifications

HY-124865 Related Classifications