2. MAPK/ERK Pathway NF-κB
  3. MAP3K IKK
  4. MAP3K14-IN-1

MAP3K14-IN-1 (Compound 173) is a MAP3K14 (NIK kinase) inhibitor with an IC50 of 1.8 nM. MAP3K14-IN-1 inhibits the autophosphorylation of MAP3K14 kinase. MAP3K14-IN-1 reduces the level of phosphorylated IKKα in cancer cells. MAP3K14-IN-1 inhibits the proliferation of multiple myeloma cells. MAP3K14-IN-1 can be used in research related to multiple myeloma.

For research use only. We do not sell to patients.

MAP3K14-IN-1

MAP3K14-IN-1 Chemical Structure

CAS No. : 2113617-02-8

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MAP3K14-IN-1 Related Antibodies

Top Publications Citing Use of Products

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MAP3K7/TAK1 MAP3K8/COT/Tpl2 MAP3K6/ASK2 MAP3K5/ASK1 MAP3K12/DLK/Pref-1 NIK/MAP3K14

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IKK-α IKK-β IKK IKKε TBK1

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Description

MAP3K14-IN-1 (Compound 173) is a MAP3K14 (NIK kinase) inhibitor with an IC50 of 1.8 nM. MAP3K14-IN-1 inhibits the autophosphorylation of MAP3K14 kinase. MAP3K14-IN-1 reduces the level of phosphorylated IKKα in cancer cells. MAP3K14-IN-1 inhibits the proliferation of multiple myeloma cells. MAP3K14-IN-1 can be used in research related to multiple myeloma[1].

IC50 & Target[1]

NIK/MAP3K14

1.8 nM (IC50)

IKKα

1.3 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
JJN-3 IC50
29 nM
Compound: 173
Antiproliferative activity against human JJN-3 cells after 96 hrs by CellTiter-Glo luminescence assay
Antiproliferative activity against human JJN-3 cells after 96 hrs by CellTiter-Glo luminescence assay
[PMID: 28947934]
KMS-12-BM IC50
>10 μM
Compound: 173
Antiproliferative activity against human KMS-12-BM cells after 96 hrs by CellTiter-Glo luminescence assay
Antiproliferative activity against human KMS-12-BM cells after 96 hrs by CellTiter-Glo luminescence assay
[PMID: 28947934]
In Vitro

MAP3K14-IN-1 inhibits autophosphorylation of recombinant MAP3K14/NIK kinase in cell-free assays, with an IC50 of 1.8 nM[1].
MAP3K14-IN-1 inhibits the level of p-IKKα in L363 multiple myeloma cells, with an IC50 of 1.3 nM[1].
MAP3K14-IN-1 inhibits the proliferation of JJN-3 multiple myeloma cells with an IC50 of 29 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAP3K14-IN-1 Related Antibodies
Molecular Weight

509.61

Formula

C29H31N7O2
CAS No.
SMILES

C(O)[C@]1(C)C=2C(=C(C#N)C=C(C2)C3=NC(NC4=CC(C#N)=C(CCN5CCOCC5)C=C4C)=NC=C3)NC1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MAP3K14-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAP3K14-IN-12113617-02-8MAP3KIKKMAP kinase kinase kinase, MEKK, MAPKKKIκB kinaseI kappa B kinaseNF-κB signaling pathwayscancer cellsKMS12-BM multiple myeloma cellsMAP3K14L363 multiple myeloma cellsIKKαserine/threonine kinasemultiple myelomaJJN-3 multiple myeloma cellsNIK kinaseInhibitorinhibitorinhibit

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