1. Immunology/Inflammation
  2. COX

COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain. Drugs, like Aspirin, that inhibit cyclooxygenase activity have been available to the public for about 100 years. Two cyclooxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Under many circumstances the COX-1 enzyme is produced constitutively (i.e., gastric mucosa) whereas COX-2 is inducible (i.e., sites of inflammation). Non-steroidal anti-inflammatory drugs (NSAID), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The main COX inhibitors are the non-steroidal anti-inflammatory drugs (NSAIDs).

COX Related Products (72):

Cat. No. Product Name Effect Purity
  • HY-14397
    Indomethacin Inhibitor
    Indomethacin is a nonselective inhibitor of COX1 and COX2, used to reduce fever, pain, stiffness, and swelling.
  • HY-66005
    Acetaminophen Inhibitor
    Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic drug.
  • HY-14617
    Paradol Inhibitor
    Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site.
  • HY-14654
    Aspirin Inhibitor
    Aspirin (acetylsalicylic acid ) is an inhibitor of COX-1 with an IC50 of 5 μg/mL; commonly used for the treatment of pain, fever, and inflammation.
  • HY-78131
    Ibuprofen Inhibitor
    Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.
  • HY-N0389
    Columbin Inhibitor
    Columbin is a diterpenoid furanolactone with anti-inflammation activity.
  • HY-N0147
    Rutaecarpine Inhibitor
    Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM.
  • HY-13913
    NS-398 Inhibitor
    NS-398 is a COX-2 inhibitor. The COX-1 activity is completely unaffected by 100 μM NS-398, whereas the COX-2 activity was concentration-dependently inhibited, the IC50 value being 3.8 μM.
  • HY-15036
    Diclofenac Inhibitor
    Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.
  • HY-15037
    Diclofenac Sodium Inhibitor
    Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.
  • HY-78131B
    (R)-(-)-Ibuprofen
    (R)-Ibuprofen, a nonsteroidal anti-inflammatory, is the less active enantiomer of ibuprofen, an inhibitor of Cox-1 and Cox-2.
  • HY-17372
    Rofecoxib Inhibitor
    Rofecoxib(MK 966) is a potent inhibitor of the COX-2-dependent production of PGE2 in human osteosarcoma cells (IC50= 26±10 nM) and Chinese hamster ovary cells expressing human COX-2 (IC50=18±7 nM).
  • HY-17009
    Iguratimod Inhibitor
    Iguratimod(T-614) is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor.
  • HY-15762
    Valdecoxib Inhibitor
    Valdecoxib (SC 65872) is a COX-2 selective inhibitor with an IC50 value of 5 nM.
  • HY-15321
    Etoricoxib Inhibitor
    Etoricoxib(MK-0663) selectively inhibited COX-2 in human whole blood assays in vitro, with an IC50 value of 1.1 ± 0.1 μM for COX-2 (LPS-induced prostaglandin E2 synthesis), compared with an IC50 value of 116 ± 8 μM for COX-1 (serum thromboxane B2 generation after clotting of the blood).
  • HY-15030
    Naproxen Inhibitor
    Naproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.
  • HY-B0008
    Sulindac Inhibitor
    Sulindac (Clinoril) is a non-steroidal anti-inflammatory agent of the arylalkanoic acid class; it is thought to act on enzymes COX-1 and COX-2, inhibiting prostaglandin synthesis.
  • HY-17357
    Nepafenac Inhibitor
    Nepafenac(AHR 9434; AL 6515; Nevanac) is a selective COX-2 inhibitor; is prodrug of Amfenac.
  • HY-15028
    ATB-346 Inhibitor
    ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
  • HY-15030A
    Naproxen sodium Inhibitor
    Naproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.