COX

COX Isoform Specific Products:

By Effects:	Inhibitors (203) Antagonists (1) Activators (4) Modulators (1)

Cat. No.	Product Name	Effect	Purity

HY-66005

Acetaminophen	Inhibitor	99.96%
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-14397

Indomethacin	Inhibitor	99.97%
Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC₅₀s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes.

HY-14398

Celecoxib Inhibitor 99.50%

Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.
HY-14654

Aspirin Inhibitor 99.90%

Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC₅₀s of 5 and 210 μg/mL.
HY-78131

Ibuprofen Inhibitor 99.97%

Ibuprofen is an anti-inflammatory agent targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.

Celecoxib	Inhibitor	99.50%
Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

Aspirin	Inhibitor	99.90%
Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC₅₀s of 5 and 210 μg/mL.

Ibuprofen	Inhibitor	99.97%
Ibuprofen is an anti-inflammatory agent targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.

HY-14397A

Indomethacin sodium hydrate	Inhibitor
Indomethacin sodium hydrate (Indometacin sodium hydrate) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC₅₀s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin sodium hydrate disrupts autophagic flux by disturbing the normal functioning of lysosomes.

HY-W012399

2,5-Di-tert-butylhydroquinone	Modulator	>98.0%
2,5-Di-tert-butylhydroquinone (DTBHQ), the indirect food additive, regulates the activity of 5-lipoxygenase as well as the activity of COX-2 (IC₅₀=1.8 and 14.1 μM for 5-LO and COX-2, respectively) .

HY-17485

Alminoprofen	Inhibitor	99.35%
Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. Alminoprofen possesses both antiphospholipase A2 (PLA2) activity and anti-cycloxygenase (COX) activity.

HY-N0898

Catechin Inhibitor 99.23%

Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

Catechin	Inhibitor	99.23%
Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-13913

NS-398	Inhibitor	99.86%
NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC₅₀ of 3.8 μM, and has no effect on COX-1 at 100 μM.

HY-N0603

20(S)-Ginsenoside Rg3	Inhibitor	98.10%
20(S)-Ginsenoside Rg3 is the main component of Red ginseng. Ginsenoside Rg3 inhibits Na⁺ and hKv1.4 channel with IC₅₀s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.

HY-N1067

Xanthohumol	Inhibitor	99.84%
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

HY-59105

SC-560 Inhibitor 99.77%

SC-560 is a potent and selective COX-1 inhibitor with an IC₅₀ of 9 nM.
HY-B0008

Sulindac Inhibitor 99.78%

Sulindac (MK-231) is a non-steroidal antiinflammatory agent, acts as a COX-2 inhibitor, and inhibits overexpression of COX-2.
HY-N0523

Gallic acid Inhibitor 99.85%

Gallic acid is an antioxidant which can inhibit both COX-2.

SC-560	Inhibitor	99.77%
SC-560 is a potent and selective COX-1 inhibitor with an IC₅₀ of 9 nM.

Sulindac	Inhibitor	99.78%
Sulindac (MK-231) is a non-steroidal antiinflammatory agent, acts as a COX-2 inhibitor, and inhibits overexpression of COX-2.

Gallic acid	Inhibitor	99.85%
Gallic acid is an antioxidant which can inhibit both COX-2.

HY-B1227

Carprofen	Inhibitor	99.96%
Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC₅₀s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-N0001

(-)-Epicatechin	Inhibitor	99.00%
(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-15030

Naproxen Inhibitor 99.96%

Naproxen is a COX-1 and COX-2 inhibitor with IC₅₀s of 8.72 and 5.15 μM, respectively in cell assay.

Naproxen	Inhibitor	99.96%
Naproxen is a COX-1 and COX-2 inhibitor with IC₅₀s of 8.72 and 5.15 μM, respectively in cell assay.

HY-15037

Diclofenac Sodium	Inhibitor	99.93%
Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-B0167

Salicylic acid Inhibitor >98.0%

Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.

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