COX

COX Isoform Specific Products:

By Effects:	Inhibitors (159) Antagonists (1) Activators (4)

Cat. No.	Product Name	Effect	Purity

HY-14398

Celecoxib Inhibitor 99.50%

Celecoxib is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

Celecoxib	Inhibitor	99.50%
Celecoxib is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

HY-66005

Acetaminophen	Inhibitor	99.96%
Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic drug. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-14397

Indomethacin Inhibitor 99.71%

Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC₅₀s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells.
HY-14654

Aspirin Inhibitor 99.90%

Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC₅₀s of 5 and 210 μg/mL.
HY-78131

Ibuprofen Inhibitor 99.99%

Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.

Indomethacin	Inhibitor	99.71%
Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC₅₀s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells.

Aspirin	Inhibitor	99.90%
Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC₅₀s of 5 and 210 μg/mL.

Ibuprofen	Inhibitor	99.99%
Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.

HY-B1227

Carprofen	Inhibitor	99.76%
Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC₅₀s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-B1452

Licofelone	Inhibitor	>99.0%
Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC₅₀=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins.

HY-135731

4-Methylamino antipyrine	Inhibitor
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic drug and can be used for pain and fever. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties.

HY-N0603

20(S)-Ginsenoside Rg3	Inhibitor	>98.0%
20(S)-Ginsenoside Rg3 is the main component of Red ginseng. Ginsenoside Rg3 inhibits Na⁺ and hKv1.4 channel with IC₅₀s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.

HY-N1067

Xanthohumol	Inhibitor	99.60%
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities.

HY-13913

NS-398	Inhibitor	99.86%
NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC₅₀ of 3.8 μM, and has no effect on COX-1 at 100 μM.

HY-N0898

Catechin Inhibitor 99.23%

Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

Catechin	Inhibitor	99.23%
Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-17372

Rofecoxib	Inhibitor	99.95%
Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC₅₀s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC₅₀ > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).

HY-B0167

Salicylic acid Inhibitor >98.0%

Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.
HY-B0008

Sulindac Inhibitor 99.78%

Sulindac (MK-231) is a non-steroidal antiinflammatory agent, acts as a COX-2 inhibitor, and inhibits overexpression of COX-2.
HY-N0002

(-)-Epicatechin gallate Inhibitor 98.57%

(-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 7.5 μM.
HY-N0147

Rutaecarpine Inhibitor 98.11%

Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC₅₀ value of 0.28 μM.
HY-N0523

Gallic acid Inhibitor 99.97%

Gallic acid is an antioxidant which can inhibit both COX-2.
HY-B0261

Meloxicam Inhibitor 98.07%

Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC₅₀s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.
HY-B0167A

Sodium Salicylate Inhibitor 99.93%

Sodium Salicylate inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.

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