COX

COX Isoform Specific Products:

By Effects:	Inhibitors (178) Antagonists (1) Activators (4)

Cat. No.	Product Name	Effect	Purity

HY-66005

Acetaminophen	Inhibitor	99.96%
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-14398

Celecoxib Inhibitor 99.50%

Celecoxib is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

Celecoxib	Inhibitor	99.50%
Celecoxib is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

HY-14397

Indomethacin	Inhibitor	99.71%
Indomethacin (Indometacin) is a potent and nonselective inhibitor of COX1 and COX2, with IC₅₀s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells.

HY-14654

Aspirin Inhibitor 99.90%

Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC₅₀s of 5 and 210 μg/mL.
HY-78131

Ibuprofen Inhibitor 99.99%

Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.

Aspirin	Inhibitor	99.90%
Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC₅₀s of 5 and 210 μg/mL.

Ibuprofen	Inhibitor	99.99%
Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.

HY-B1227

Carprofen	Inhibitor	99.76%
Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC₅₀s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-N0774

Isofraxidin	Inhibitor	98.14%
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation.

HY-135731

4-Methylamino antipyrine	Inhibitor
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic drug and can be used for pain and fever. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties.

HY-N0898

Catechin Inhibitor 99.23%

Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

Catechin	Inhibitor	99.23%
Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-N0603

20(S)-Ginsenoside Rg3	Inhibitor	>98.0%
20(S)-Ginsenoside Rg3 is the main component of Red ginseng. Ginsenoside Rg3 inhibits Na⁺ and hKv1.4 channel with IC₅₀s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.

HY-13913

NS-398	Inhibitor	99.86%
NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC₅₀ of 3.8 μM, and has no effect on COX-1 at 100 μM.

HY-N0523

Gallic acid Inhibitor 99.85%

Gallic acid is an antioxidant which can inhibit both COX-2.

Gallic acid	Inhibitor	99.85%
Gallic acid is an antioxidant which can inhibit both COX-2.

HY-N1067

Xanthohumol	Inhibitor	99.60%
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

HY-B0008

Sulindac Inhibitor 99.78%

Sulindac (MK-231) is a non-steroidal antiinflammatory agent, acts as a COX-2 inhibitor, and inhibits overexpression of COX-2.

Sulindac	Inhibitor	99.78%
Sulindac (MK-231) is a non-steroidal antiinflammatory agent, acts as a COX-2 inhibitor, and inhibits overexpression of COX-2.

HY-17372

Rofecoxib	Inhibitor	99.95%
Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC₅₀s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC₅₀ > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).

HY-B0167

Salicylic acid Inhibitor >98.0%

Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.
HY-B0167A

Sodium Salicylate Inhibitor 99.93%

Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.
HY-N0002

(-)-Epicatechin gallate Inhibitor 98.57%

(-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 7.5 μM.
HY-59105

SC-560 Inhibitor 99.58%

SC-560 is a potent and selective COX-1 inhibitor with an IC₅₀ of 9 nM.

Salicylic acid	Inhibitor	>98.0%
Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.

Sodium Salicylate	Inhibitor	99.93%
Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.

(-)-Epicatechin gallate	Inhibitor	98.57%
(-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 7.5 μM.

SC-560	Inhibitor	99.58%
SC-560 is a potent and selective COX-1 inhibitor with an IC₅₀ of 9 nM.

HY-N0001

(-)-Epicatechin	Inhibitor	99.00%
(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

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