Signaling Pathway

COX

COX

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Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain. Drugs, like aspirin, that inhibit cyclooxygenase activity have been available to the public for about 100 years. Two cyclooxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Under many circumstances the COX-1 enzyme is produced constitutively (i.e., gastric mucosa) whereas COX-2 is inducible (i.e., sites of inflammation). Non-steroidal anti-inflammatory drugs (NSAID), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The main COX inhibitors are the non-steroidal anti-inflammatory drugs (NSAIDs).

COX Inhibitors & Modulators (71)

Product Name Catalog No. Brief Description
(-)-Epicatechin

HY-N0001

(-)-Epicatechin is a naturally occurring flavanol; a likely candidate for cocoa-based product reported reductions in cardiometabolic risk.

(-)-Epicatechin gallate

HY-N0002

(-)-Epicatechin gallate is a flavan-3-ol, a type of flavonoid, present in green tea.

(R)-(-)-Ibuprofen

HY-78131B

(R)-Ibuprofen, a nonsteroidal anti-inflammatory, is the less active enantiomer of ibuprofen, an inhibitor of Cox-1 and Cox-2.

(S)-(+)-Ibuprofen

HY-78131A

S(+)-Ibuprofen is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor.

1-O-Acetylbritannilactone

HY-N0896

1-O-Acetylbritannilactone(Inulicin) is a sesquiterpene isolated from the medicinal plant Inula britannica; anticancer and anti-inflammation acitvity.

Aceclofenac

HY-B0634

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac.

Acemetacin

HY-B0482

Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.

Acetaminophen

HY-66005

Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor.

Ampiroxicam

HY-17484

Ampiroxicam(CP65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.

Asarylaldehyde

HY-100580

Asarylaldehyde is a natural COX-2 inhibitor, which isolated from carrot (Daucus carota L.

Aspirin

HY-14654

ATB-346

HY-15028

ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.

Bufexamac

HY-B0494

Bufexamac is a COX inhibitor used as an anti-inflammatory agent.

Carprofen

HY-B1227

Carprofen reduces inflammation by inhibition of COX-2 and other sources of inflammatory prostaglandins, does not interfere with COX-1 activity.

Celecoxib

HY-14398

Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM.

Columbin

HY-N0389

Columbina is a diterpenoid furanolactone with anti-inflammation activity.

Deracoxib

HY-17509

Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID).

Diclofenac

HY-15036

Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.

Diclofenac diethylamine

HY-15036A

Diclofenac Diethylamine is a non-selective COX inhibitor used as a nonsteroidal anti-inflammatory drug (NSAID).

Diclofenac Sodium

HY-15037

Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.