1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. ROR

ROR

The retinoic acid-related orphan receptor (ROR) subgroup of nuclear receptors consists of three members, RORα, -β and -γ (NR1F1-3 or RORA-C). RORs regulate several important physiological processes and have been implicated in a number of pathologies. RORα is critical for cerebellar development and bone formation, while RORβ regulates functions in the brain and retina. RORγ plays a key role in lymph node development and thymopoiesis. Furthermore, both RORα and RORγ are involved in regulating various metabolic pathways, inflammatory responses and immune functions, including Th17 cell differentiation.

The retinoic acid receptor-related orphan receptors α and γ (RORα and RORγ), are key regulators of helper T (Th)17 cell differentiation, which is involved in the innate immune system and autoimmune disorders. RORα/γ are members of the nuclear hormone receptor superfamily, which contains a signature type II zinc finger DNA binding motif and a hydrophobic ligand binding pocket.

ROR Related Products (21):

Cat. No. Product Name Effect Purity
  • HY-104037
    Cintirorgon Agonist 99.95%
    Cintirorgon (LYC-55716) is novel oral RAR-related orphan receptor γ (RORγ) agonist.
  • HY-14422
    SR1078 Agonist 99.83%
    SR1078 is an agonist of retinoic acid receptor-related orphan receptor α/γ (RORα/RORγ).
  • HY-14413
    SR3335 Antagonist 98.02%
    SR3335 is a selective RORα inverse agonist that directly binds to RORα with a Ki of 220 nM.
  • HY-13421
    SR1001 Inhibitor 99.79%
    SR1001 is a selective RORα and RORγ inverse agonist with Kis 172 and 111 nM, respectively.
  • HY-12776
    GSK805 Inhibitor
    GSK805 is a potent, orally bioavailable RORγγ Inhibitor with pIC50 of 8.4 and >8.2 for RORγ FRET assay and Th17 assay.
  • HY-120384
    AZD-0284 Antagonist
    AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders.
  • HY-112706
    PF-06747711 Antagonist
    PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity.
  • HY-111748
    RORγt Inverse agonist 2 Antagonist
    RORγt Inverse agonist 2 is a selective, orally active RORγt inverse agonist with an EC50 of 119 nM.
  • HY-19770
    GSK2981278 Modulator 99.77%
    GSK2981278 is a retinoid-related orphan receptor gamma (RORy) modulator, extracted from patent WO/2015061515 A1, example 124.
  • HY-16998
    SR2211 Antagonist >98.0%
    SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM.
  • HY-101454
    SR0987 Agonist 99.56%
    SR0987 is a RORγt agonist, with an EC50 of 800 nM.
  • HY-128604
    XY101 Inhibitor
    XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC50 of 30 nM and a Kd of 380 nM.
  • HY-128573
    RORγt Inverse agonist 3 Antagonist
    RORγt Inverse agonist 3 is a potent, selective and orally active RORγ inverse agonist, with EC50s of 0.22 μM and 0.15 μM for hRORγ and RORγt (human IL-17 cells), respectively.
  • HY-111509
    TAK-828F Antagonist
    TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (binding IC50=1.9 nM, reporter gene IC50=6.1 nM). TAK-828F shows excellent RORγt isoforms selectivity (>5000-fold selectivity against human RORα and RORβ).
  • HY-119366
    S18-000003 Inhibitor
    S18-000003 is a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor with an IC50 of 29 nM. S18-000003 inhibits IL-17 production.
  • HY-128353
    ROR agonist-1 Antagonist
    ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5.
  • HY-19774
    GNE-0946 Inhibitor
    GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC50 value of 4 nM for HEK-293 cell.
  • HY-19775
    GNE-6468 Inhibitor
    GNE-6468 is a potent and selective RORγ(RORc) agonists with an EC50 value of 13 nM for HEK-293 cell.
  • HY-102075
    TMP778 Antagonist
    TMP778 is a potent and selevtive RORγt inverse agonist, with an IC50 of 7 nM in FRET assay.
  • HY-100084
    L 601920-0 Modulator
    L 601920-0 is a ROR gamma modulator extracted from patent US20110263046 A1, in figure 2.
Isoform Specific Products

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