1. Metabolic Enzyme/Protease
  2. ROR

ROR

The retinoic acid-related orphan receptor (ROR) subgroup of nuclear receptors consists of three members, RORα, -β and -γ (NR1F1-3 or RORA-C). RORs regulate several important physiological processes and have been implicated in a number of pathologies. RORα is critical for cerebellar development and bone formation, while RORβ regulates functions in the brain and retina. RORγ plays a key role in lymph node development and thymopoiesis. Furthermore, both RORα and RORγ are involved in regulating various metabolic pathways, inflammatory responses and immune functions, including Th17 cell differentiation.

The retinoic acid receptor-related orphan receptors α and γ (RORα and RORγ), are key regulators of helper T (Th)17 cell differentiation, which is involved in the innate immune system and autoimmune disorders. RORα/γ are members of the nuclear hormone receptor superfamily, which contains a signature type II zinc finger DNA binding motif and a hydrophobic ligand binding pocket.

ROR Related Products (13):

Cat. No. Product Name Effect Purity
  • HY-14422
    SR1078 Agonist 99.83%
    SR1078 is an agonist of retinoic acid receptor-related orphan receptor α/γ (RORα/RORγ).
  • HY-104037
    LYC-55716 Agonist 99.95%
    LYC-55716 is novel oral RAR-related orphan receptor γ (RORγ) agonist.
  • HY-14413
    SR3335 Antagonist 98.02%
    SR3335 is a selective RORα inverse agonist that directly binds to RORα with a Ki of 220 nM.
  • HY-12776
    GSK805 Inhibitor 98.05%
    GSK805 is a potent, orally bioavailable RORγγ Inhibitor with pIC50 of 8.4 and >8.2 for RORγ FRET assay and Th17 assay.
  • HY-13421
    SR1001 Agonist 99.79%
    SR1001 is a selective RORα and RORγ inverse agonist with Kis 172 and 111 nM, respectively.
  • HY-16998
    SR2211 Agonist >98.0%
    SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM.
  • HY-19774
    GNE-0946 Inhibitor
    GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC50 value of 4 nM for HEK-293 cell.
  • HY-19775
    GNE-6468 Inhibitor
    GNE-6468 is a potent and selective RORγ(RORc) agonists with an EC50 value of 13 nM for HEK-293 cell.
  • HY-19770
    GSK2981278 Modulator 99.77%
    GSK2981278 is a retinoid-related orphan receptor gamma (RORy) modulator, extracted from patent WO/2015061515 A1, example 124.
  • HY-101454
    SR0987 Agonist 99.56%
    SR0987 is a RORγt agonist, with an EC50 of 800 nM.
  • HY-100084
    L 601920-0 Modulator
    L 601920-0 is a ROR gamma modulator extracted from patent US20110263046 A1, in figure 2.
  • HY-102075
    TMP778 Agonist
    TMP778 is a potent and selevtive RORγt inverse agonist, with an IC50 of 7 nM in FRET assay.
  • HY-103637
    RORγ-IN-1 Inhibitor
    RORγ-IN-1 is a RORγ inhibitor extracted from patent US 9481674 B1, has a Ki of <100 nM.
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