1. Metabolic Enzyme/Protease
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  3. Cintirorgon

Cintirorgon (Synonyms: LYC-55716)

Cat. No.: HY-104037 Purity: 99.95%
Handling Instructions

Cintirorgon (LYC-55716) est un agoniste de RORγ premier de sa catégorie, sélectif et biodisponible par voie orale. Cintirorgon (LYC-55716) module l'expression génique des cellules immunitaires des lymphocytes T exprimant RORγ, ce qui entraîne une fonction effectrice améliorée, ainsi qu'une diminution de l'immunosuppression, entraînant une diminution de la croissance tumorale et une amélioration de la survie.

Cintirorgon (LYC-55716) is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival.

For research use only. We do not sell to patients.

Cintirorgon Chemical Structure

Cintirorgon Chemical Structure

CAS No. : 2055536-64-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 239 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 239 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 90 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 790 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1400 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Cintirorgon (LYC-55716) is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival[1][2].

IC50 & Target

RORγ[1]

In Vivo

Upon oral administration of RORγ agonist Cintirorgon (LYC-55716), this agent selectively binds to the nuclear receptor transcription factor RORγ, forming a receptor complex that translocates to the nucleus, and binds to ROR response elements (ROREs), enhancing the function, proliferation and survival of type 17 T cells, including Th17 (helper T cells) and Tc17 (cytotoxic T cells). RORγ, the nuclear receptor transcription factor that is involved in Th17/Tc17 differentiation, plays a key role in immune activation. Cintirorgon (LYC-55716) is also orally bioavailable, while the new generation of immuno-oncology drugs-ncluding PD-1/PD-L1 inhibitors are delivered by injection[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

603.53

Formula

C₂₇H₂₃F₆NO₆S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 113.3 mg/mL (187.73 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6569 mL 8.2846 mL 16.5692 mL
5 mM 0.3314 mL 1.6569 mL 3.3138 mL
10 mM 0.1657 mL 0.8285 mL 1.6569 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% saline

    Solubility: ≥ 2.5 mg/mL (4.14 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Cintirorgon
Cat. No.:
HY-104037
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