1. Metabolic Enzyme/Protease
  2. ROR

Cintirorgon (Synonyms: LYC-55716)

Cat. No.: HY-104037 Purity: 99.95%
Handling Instructions

Cintirorgon (LYC-55716) is novel oral RAR-related orphan receptor γ (RORγ) agonist.

For research use only. We do not sell to patients.

Cintirorgon Chemical Structure

Cintirorgon Chemical Structure

CAS No. : 2055536-64-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 717 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 540 In-stock
Estimated Time of Arrival: December 31
10 mg USD 900 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2700 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3960 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Cintirorgon (LYC-55716) is novel oral RAR-related orphan receptor γ (RORγ) agonist.

IC50 & Target

RORγ[1]

In Vivo

Cintirorgon (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improves survival in in vivo. Upon oral administration of RORγ agonist Cintirorgon (LYC-55716), this agent selectively binds to the nuclear receptor transcription factor RORγ, forming a receptor complex that translocates to the nucleus, and binds to ROR response elements (ROREs), enhancing the function, proliferation and survival of type 17 T cells, including Th17 (helper T cells) and Tc17 (cytotoxic T cells). This may increase the expression of co-stimulatory molecules and decrease the expression of co-inhibitory molecules on T cells leading to increased production of cytokines and chemokines by T cells, decreases proliferation of regulatory T cells (Tregs), and abrogation of tumor-induced immunosuppression. This ultimately induces a T-cell-mediated immune response against cancer cells and leads to a reduction in tumor cell growth. RORγ, the nuclear receptor transcription factor that is involved in Th17/Tc17 differentiation, plays a key role in immune activation. Cintirorgon (LYC-55716) is also orally bioavailable, while the new generation of immuno-oncology drugs-ncluding PD-1/PD-L1 inhibitors are delivered by injection[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 113.3 mg/mL (187.73 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6569 mL 8.2846 mL 16.5692 mL
5 mM 0.3314 mL 1.6569 mL 3.3138 mL
10 mM 0.1657 mL 0.8285 mL 1.6569 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

603.53

Formula

C₂₇H₂₃F₆NO₆S

CAS No.

2055536-64-4

SMILES

O=C(O)C(C)(C)C[[email protected]@H]1OC2=CC=C(C3=CC(F)=CC(OC(F)F)=C3)C=C2N(S(=O)(C4=CC=CC(C(F)(F)F)=C4)=O)C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Cintirorgon
Cat. No.:
HY-104037
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Cintirorgon

Cat. No.: HY-104037