Cintirorgon sodium
Based on 9 publication(s) in Google Scholar
Cintirorgon sodium is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon sodium (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival.
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- CAS No.: 2055538-47-9
- Formule: C27H22F6NNaO6S
- Masse moléculaire:625.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Cintirorgon sodium
More- Pharmacol Res. 2021 Oct:172:105793. [Abstract]
- Diabetes. 2023 Nov 1;72(11):1534-1546. [Abstract]
- Eur J Med Chem. 2021 Oct 15:222:113585. [Abstract]
- Antiviral Res. 2024 Jan:221:105769. [Abstract]
- bioRxiv. 2026 Apr 1:2026.03.31.715684. [Abstract]
- Patent. US20240325538A1.
- Patent. US20240238271A1.
- Patent. US20230226111A1.
- Heliyon. 2023 Jun 28;9(7):e17766. [Abstract]
Activité biologique
Chemical Information
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CAS No. 2055538-47-9
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Masse moléculaire 625.51
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Formule C27H22F6NNaO6S
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SMILES
O=C(O[Na])C(C)(C)C[C@@H]1OC2=CC=C(C3=CC(F)=CC(OC(F)F)=C3)C=C2N(S(=O)(C4=CC=CC(C(F)(F)F)=C4)=O)C1
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Synonyms
LYC-55716 sodium
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (9)
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Journal Impact Factor
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Most Recent
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Pharmacol Res
RORγt agonist synergizes with CTLA-4 antibody to inhibit tumor growth through inhibition of Treg cells via TGF-β signaling in cancer. [Abstract]2021 Oct:172:105793. PMID: 34339836 -
Diabetes
Chronic Glucocorticoid Exposure Induced a S1PR2-RORγ Axis to Enhance Hepatic Gluconeogenesis in Male Mice. [Abstract]2023 Nov 1;72(11):1534-1546. PMID: 37552863 -
Eur J Med Chem
Discovery of novel N-sulfonamide-tetrahydroisoquinolines as potent retinoic acid receptor-related orphan receptor γt agonists. [Abstract]2021 Oct 15:222:113585. PMID: 34118722 -
Antiviral Res
Validation of nuclear receptor RORγ isoform 1 as a novel host-directed antiviral target based on the modulation of cholesterol levels. [Abstract]2024 Jan:221:105769. PMID: 38056603 -
bioRxiv
Efficient Generation of Functional TCRαβ+ Cytotoxic T Cells from hiPSCs via Small-Molecule Modulation. [Abstract]2026 Apr 1:2026.03.31.715684. PMID: 41959015 -
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Heliyon
Astragalus regulates the intestinal immune response during sepsis by mediating ILC3 proliferation through RORγt. [Abstract]2023 Jun 28;9(7):e17766. PMID: 37539221
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cintirorgon sodium Related Classifications
HY-104037A Related Classifications
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