Cintirorgon sodium
Based on 9 publication(s) in Google Scholar
Cintirorgon sodium is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon sodium (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival.
For research use only. We do not sell to patients.
- CAS No.: 2055538-47-9
- Formula: C27H22F6NNaO6S
- Molecular Weight:625.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Cintirorgon sodium
More- Pharmacol Res. 2021 Oct:172:105793. [Abstract]
- Diabetes. 2023 Nov 1;72(11):1534-1546. [Abstract]
- Eur J Med Chem. 2021 Oct 15:222:113585. [Abstract]
- Antiviral Res. 2024 Jan:221:105769. [Abstract]
- Heliyon. 2023 Jun 28;9(7):e17766. [Abstract]
- bioRxiv. 2026 Apr 1:2026.03.31.715684. [Abstract]
- Patent. US20240325538A1.
- Patent. US20240238271A1.
- Patent. US20230226111A1.
Biological Activity
Chemical Information
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CAS No. 2055538-47-9
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Molecular Weight 625.51
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Formula C27H22F6NNaO6S
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SMILES
O=C(O[Na])C(C)(C)C[C@@H]1OC2=CC=C(C3=CC(F)=CC(OC(F)F)=C3)C=C2N(S(=O)(C4=CC=CC(C(F)(F)F)=C4)=O)C1
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Synonyms
LYC-55716 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (9)
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Journal Impact Factor
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Most Recent
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Pharmacol Res
RORγt agonist synergizes with CTLA-4 antibody to inhibit tumor growth through inhibition of Treg cells via TGF-β signaling in cancer. [Abstract]2021 Oct:172:105793. PMID: 34339836 -
Diabetes
Chronic Glucocorticoid Exposure Induced a S1PR2-RORγ Axis to Enhance Hepatic Gluconeogenesis in Male Mice. [Abstract]2023 Nov 1;72(11):1534-1546. PMID: 37552863 -
Eur J Med Chem
Discovery of novel N-sulfonamide-tetrahydroisoquinolines as potent retinoic acid receptor-related orphan receptor γt agonists. [Abstract]2021 Oct 15:222:113585. PMID: 34118722 -
Antiviral Res
Validation of nuclear receptor RORγ isoform 1 as a novel host-directed antiviral target based on the modulation of cholesterol levels. [Abstract]2024 Jan:221:105769. PMID: 38056603 -
Heliyon
Astragalus regulates the intestinal immune response during sepsis by mediating ILC3 proliferation through RORγt. [Abstract]2023 Jun 28;9(7):e17766. PMID: 37539221 -
bioRxiv
Efficient Generation of Functional TCRαβ+ Cytotoxic T Cells from hiPSCs via Small-Molecule Modulation. [Abstract]2026 Apr 1:2026.03.31.715684. PMID: 41959015 -
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Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cintirorgon sodium Related Classifications
HY-104037A Related Classifications
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