ROR Inhibitors

RORγ

RORα

RORβ

ROR Inhibitors, Agonists, Antagonists, Activators & Modulators

Product Name	RORγ	RORα	RORβ	Purity
XY018	ROR-γ, IC₅₀: 0.19 μM (in 293 T cells)	ROR-α, IC₅₀: 7.57 μM (in 293 T cells)		99.90%
GNE-6468	ROR-γ, EC₅₀: 2 nM			98.04%
RORγt inverse agonist 13	ROR-γ, IC₅₀: 63.8 nM			98.13%
S18-000003	RORγt, IC₅₀: <30 nM			99.31%
Vimirogant hydrochloride	RORγt, Ki: 3.5 nM RORγt, IC₅₀: 17 nM			98.33%
7ß,27-Dihydroxycholesterol	RORγt, Ki: 120 nM			≥99.0%
Zymostenol	RORγ, EC₅₀: 1 μM
JNJ-61803534	RORγt			99.88%
BMS-986251	RORγt, EC₅₀: 12 nM	RORα, EC₅₀: >10 μM	RORβ, EC₅₀: >10 μM
RORγt Inverse agonist 10	RORγt, IC₅₀: 51 nM			99.13%
A-9758	RORγt, IC₅₀: 5 nM
SHR168442	ROR-γ
RORγt modulator 5	RORγt, Ki: <100 nM
SR1555	RORγ, IC₅₀: 1 μM
RORγt modulator 4	RORγt
(±)-ML 209	RORγ, IC₅₀: 1.1 μM
RORγt inverse agonist 29	RORγt, IC₅₀: 21 nM
CD12681	RORγ
RORγt inverse agonist 30	RORγt, IC₅₀: 46 nM
Vimirogant	RORγt, Ki: 3.5 nM RORγt, IC₅₀: 17 nM

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