1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. NEDD8-activating Enzyme

NEDD8-activating Enzyme

NEDD8-activating enzyme (NAE) is upstream of the 20S proteasome in the ubiquitin/proteasome pathway and catalyzes the first step in the neddylation pathway. NAE is an essential component of the NEDD8 conjugation pathway that controls the activity of the cullin-RING subtype of ubiquitin ligases, thereby regulating the turnover of a subset of proteins upstream of the proteasome. Substrates of cullin-RING ligases have important roles in cellular processes associated with cancer cell growth and survival pathways.

The ubiquitin-like protein NEDD8 is a critical signaling molecule implicated in the functional maintenance and homeostasis of cells. Dysregulation of this process is involved in a variety of human diseases, including cancer. Therefore, NEDD8-activating enzyme E1 (NAE), the only activation enzyme of the neddylation pathway, has been an emergent anticancer target.

NEDD8-activating Enzyme Related Products (7):

Cat. No. Product Name Effect Purity
  • HY-70062
    Pevonedistat
    Inhibitor ≥98.0%
    Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC50 of 4.7 nM.
  • HY-10484
    Pevonedistat hydrochloride
    Inhibitor ≥98.0%
    Pevonedistat hydrochloride (MLN4924 hydrochloride) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC50 of 4.7 nM.
  • HY-128586
    TAS4464
    Inhibitor 98.55%
    TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM.
  • HY-111505
    NAcM-OPT
    Inhibitor 98.60%
    NAcM-OPT is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor, which potently inhibits the DCN1-UBE2M interaction.
  • HY-101790A
    ZM223 hydrochloride
    Inhibitor 98.93%
    ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme (NAE) inhibitor with excellent anticancer activity.
  • HY-128586A
    TAS4464 hydrochloride
    Inhibitor 98.88%
    TAS4464 (hydrochloride) is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM.
  • HY-101790
    ZM223
    Inhibitor
    ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active.
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