1. Metabolic Enzyme/Protease
  2. NEDD8-activating Enzyme
  3. ZM223 hydrochloride

ZM223 hydrochloride 

Cat. No.: HY-101790A Purity: 98.00%
Handling Instructions

ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme (NAE) inhibitor with excellent anticancer activity.

For research use only. We do not sell to patients.

ZM223 hydrochloride Chemical Structure

ZM223 hydrochloride Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 534 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of ZM223 hydrochloride:

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Description

ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme (NAE) inhibitor with excellent anticancer activity[1].

IC50 & Target

NEDD8 activating enzyme (NAE)[1]

In Vitro

ZM223 hydrochloride (0.1-1 μM; 4 hours) inhibits both HCT-116 and U-2OS cancer cells with IC50s of 100 and 122 nM, respectively[1].
ZM223 hydrochloride (0.1-1 μM; 4 hours) causes a dose-response decrease in the level of NEDD8 and accumulation of the UBC12 protein, indicating the decrease of the subsequent NEDD8-UBC12 complex[1].

Cell Viability Assay[1]

Cell Line: HCT116 colon cancer cells and U-2OS osteosarcoma cells
Concentration: 0.1 μM, 1 μM
Incubation Time: 4 hours
Result: Inhibited both HCT-116 and U-2OS cancer cells.

Western Blot Analysis[1]

Cell Line: HCT116 colon cancer cells
Concentration: 0.1 μM, 1 μM
Incubation Time: 4 hours
Result: Caused a decrease in the level of NEDD8 and an increase in the downstream UBC12 protein.
Molecular Weight

538.99

Formula

C₂₃H₁₈ClF₃N₄O₂S₂

SMILES

O=C(C1=CC=C(C(F)(F)F)C=C1)NC2=NC3=CC=C(NC(CSC4=CC=C(N)C=C4)=O)C=C3S2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (278.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8553 mL 9.2766 mL 18.5532 mL
5 mM 0.3711 mL 1.8553 mL 3.7106 mL
10 mM 0.1855 mL 0.9277 mL 1.8553 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 7.5 mg/mL (13.91 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
ZM223 hydrochloride
Cat. No.:
HY-101790A
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