1. Metabolic Enzyme/Protease
  2. NEDD8-activating Enzyme
  3. ZM223 hydrochloride

ZM223 hydrochloride 

Cat. No.: HY-101790A
Handling Instructions

ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme (NAE) inhibitor with excellent anticancer activity.

For research use only. We do not sell to patients.

ZM223 hydrochloride Chemical Structure

ZM223 hydrochloride Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 534 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 Get quote
100 mg USD 3350 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of ZM223 hydrochloride:

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Description

ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme (NAE) inhibitor with excellent anticancer activity[1].

IC50 & Target

NEDD8 activating enzyme (NAE)[1]

In Vitro

ZM223 hydrochloride causes a decrease in the level of NEDD8 and an increase in the downstream UBC12 protein[1].
ZM223 hydrochloride inhibits HCT116 colon cancer cells with an IC50 value of 100 nM[1].

Molecular Weight

538.99

Formula

C₂₃H₁₈ClF₃N₄O₂S₂

SMILES

O=C(C1=CC=C(C(F)(F)F)C=C1)NC2=NC3=CC=C(NC(CSC4=CC=C(N)C=C4)=O)C=C3S2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Product Name:
ZM223 hydrochloride
Cat. No.:
HY-101790A
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