1. Recombinant Proteins
  2. Viral Proteins
  3. SARS-CoV-2 Proteins

SARS-CoV is the coronavirus (CoV) that causes severe acute respiratory syndrome (SARS). CoVs are enveloped viruses with a positive-sense, single-stranded RNA and can cause health-threatening outbreaks by targeting human respiratory system, including not only SARS, but also Middle East respiratory syndrome (MERS) and SARS-CoV-2 (the cause of COVID-19). CoVs have four main structural proteins: spike(S), membrane (M), envelope (E), and nucleocapsid (N) proteins. An S protein mediates the CoV entry into host cells by attaching to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), followed by fusion between virus and host cell membranes. Genome replication and subgenomic RNA transcription after entry carry on with the participation of many nonstructural proteins such as Mpro (main protease or 3CLpro), PLpro (papain-like protease) and RdRp (RNA-dependent RNA polymerase). Then the structural proteins are translated, assembled into mature virions, and released via vesicles by exocytosis. It is worth mentioning that a protease called TMPRSS2 (transmembrane protease, serine 2) play important roles throughout the whole life of CoVs (such as attachment, assembling and release) by cleaving S protein. All the proteins and subcellular structures participated in the life cycle of CoVs are promising targets for treatment of disease caused by CoVs.

Cat. No. Product Name / Synonyms Species Source
  • HY-P72035
    SARS-CoV-2 S glycoprotein (HEK293, His, Flag)

    E2 Peplomer protein

    Virus HEK293
    The SARS-CoV-2 S glycoprotein is critical in infection, binding to the ACE2 receptor and allowing viral particles to attach to the host cell membrane. Cleavage of S2/S2′ triggers cell membrane fusion or internalization via endocytosis. SARS-CoV-2 S glycoprotein (HEK293, His, Flag) is the recombinant Virus-derived SARS-CoV-2 S glycoprotein, expressed by HEK293 , with N-10*His, C-Flag labeled tag. The total length of SARS-CoV-2 S glycoprotein (HEK293, His, Flag) is 670 a.a., with molecular weight of ~120 kDa.
  • HY-P72038
    SARS-CoV-2 S glycoprotein (HEK293, His-mFc)

    Spike glycoproteinRBD; ,Spike Protein RBD;

    Virus HEK293
    The SARS-CoV-2 S glycoprotein is critical in infection, binding to the ACE2 receptor and allowing viral particles to attach to the host cell membrane. Cleavage of S2/S2′ triggers cell membrane fusion or internalization via endocytosis. SARS-CoV-2 S glycoprotein (HEK293, His-mFc) is the recombinant Virus-derived SARS-CoV-2 S glycoprotein, expressed by HEK293 , with C-mFc, C-6*His labeled tag. The total length of SARS-CoV-2 S glycoprotein (HEK293, His-mFc) is 223 a.a., with molecular weight (glycosylation form) of ~66.0 kDa.
  • HY-P72045
    SARS-CoV S Protein (HEK293, His-Myc)

    S glycoprotein; E2; Peplomer protein; Spike protein S1; Spike protein S2;

    Virus HEK293
    The SARS-CoV S protein coordinates viral entry by interacting with human ACE2 and CLEC4M/DC-SIGNR receptors to attach viral particles to the cell membrane. It downregulates host tethering protein (BST2) through lysosomal degradation, antagonizing its antiviral activity. SARS-CoV S Protein (HEK293, His-Myc) is the recombinant Virus-derived SARS-CoV S protein, expressed by HEK293 , with N-10*His, C-Myc labeled tag. The total length of SARS-CoV S Protein (HEK293, His-Myc) is 222 a.a., with molecular weight of ~37 kDa.
  • HY-P73396
    SARS-CoV-2 S Protein RBD (HEK293)

    2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD

    Virus HEK293
    The SARS-Cov-2 S glycoprotein is a SARS-Cov-2 S glycoprotein. The amino acid sequence 1261-1267a.a of the SARS-Cov-2 S glycoprotein is transmembrane. The SARS-Cov-2 S glycoprotein is a highly glycosylated trimer, each of which consists of 1260 amino acids (residues 14-1273), divided into four structural domains: the n-terminal domain (NTD), the c-terminal domain (CTD, also known as the receptor-binding domain, RBD), and two subdomains (SD1 and SD2). SARS-CoV-2 S Protein RBD (HEK293) is the recombinant Virus-derived SARS-CoV-2 S protein RBD, expressed by HEK293 , with tag free. The total length of SARS-CoV-2 S Protein RBD (HEK293) is 223 a.a., with molecular weight of approximately 34 kDa.
  • HY-P74445
    SARS-CoV-2 S1 Protein (Omicron, B.1.1.529, His)

    SARS-CoV-2 Protein; SARS-CoV-2 Spike Protein

    Virus HEK293
    The SARS-Cov-2 S glycoprotein is a SARS-Cov-2 S glycoprotein. The amino acid sequence 1261-1267a.a of the SARS-Cov-2 S glycoprotein is transmembrane. The SARS-Cov-2 S glycoprotein is a highly glycosylated trimer, each of which consists of 1260 amino acids (residues 14-1273), divided into four structural domains: the n-terminal domain (NTD), the c-terminal domain (CTD, also known as the receptor-binding domain, RBD), and two subdomains (SD1 and SD2). SARS-CoV-2 S1 Protein (Omicron, B.1.1.529, His) is the recombinant Virus-derived SARS-CoV-2 S1 protein, expressed by HEK293 , with C-His labeled tag. The total length of SARS-CoV-2 S1 Protein (Omicron, B.1.1.529, His) is 670 a.a., with molecular weight of ~99.56 kDa.
  • HY-P74444
    SARS-CoV-2 S Protein (Omicron, B.1.1.529, His)

    SARS-CoV-2 Protein; SARS-CoV-2 Spike Protein

    Virus HEK293
    The SARS-Cov-2 S glycoprotein is a SARS-Cov-2 S glycoprotein. The amino acid sequence 1261-1267a.a of the SARS-Cov-2 S glycoprotein is transmembrane. The SARS-Cov-2 S glycoprotein is a highly glycosylated trimer, each of which consists of 1260 amino acids (residues 14-1273), divided into four structural domains: the n-terminal domain (NTD), the c-terminal domain (CTD, also known as the receptor-binding domain, RBD), and two subdomains (SD1 and SD2). SARS-CoV-2 S Protein (Omicron, B.1.1.529, His) is the recombinant Virus-derived SARS-CoV-2 S protein, expressed by HEK293 , with C-His labeled tag. SARS-CoV-2 S Protein (Omicron, B.1.1.529, His), has molecular weight of ~136.67 kDa.
  • HY-P74447
    SARS-CoV-2 S Protein RBD (Omicron, B.1.1.529, His)

    SARS-CoV-2 RBD Protein; SARS-CoV-2 Spike RBD Protein; SARS-CoV-2 S Protein RBD

    Virus HEK293
    The SARS-Cov-2 S glycoprotein is a SARS-Cov-2 S glycoprotein. The amino acid sequence 1261-1267a.a of the SARS-Cov-2 S glycoprotein is transmembrane. The SARS-Cov-2 S glycoprotein is a highly glycosylated trimer, each of which consists of 1260 amino acids (residues 14-1273), divided into four structural domains: the n-terminal domain (NTD), the c-terminal domain (CTD, also known as the receptor-binding domain, RBD), and two subdomains (SD1 and SD2). SARS-CoV-2 S Protein RBD (Omicron, B.1.1.529, His) is the recombinant Virus-derived SARS-CoV-2 S protein RBD, expressed by HEK293 , with C-His labeled tag. The total length of SARS-CoV-2 S Protein RBD (Omicron, B.1.1.529, His) is 223 a.a., with molecular weight of ~26.83 kDa.
  • HY-P78106
    SARS-CoV-2 S Trimer Protein (Biotinylated, HEK293, His-Avi)

    S protein; Spike glycoprotein; S glycoprotein; COVID-19

    Virus HEK293
    SARS-CoV-2 S1 Protein, in its Spike protein S1 form, initiates infection by attaching the virion to the cell membrane through host receptor interaction. Simultaneously, Spike protein S2' acts as a viral fusion peptide, revealing itself after S2 cleavage during virus endocytosis. SARS-CoV-2 S Trimer Protein (Biotinylated, HEK293, His-Avi) is the recombinant Virus-derived SARS-CoV-2 S Trimer protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of SARS-CoV-2 S Trimer Protein (Biotinylated, HEK293, His-Avi) is 1173 a.a., with molecular weight of 140-170 kDa.
  • HY-P78282
    SARS-COV-2 S Trimer Protein (HEK293, Fc)

    S protein; Spike glycoprotein; S glycoprotein; COVID-19

    Virus HEK293
    SARS-CoV-2 S1 Protein, in its Spike protein S1 form, initiates infection by attaching the virion to the cell membrane through host receptor interaction. Simultaneously, Spike protein S2' acts as a viral fusion peptide, revealing itself after S2 cleavage during virus endocytosis. SARS-COV-2 S Trimer Protein (HEK293, Fc) is the recombinant Virus-derived SARS-COV-2 S Trimer protein, expressed by HEK293 , with C-hFc labeled tag. The total length of SARS-COV-2 S Trimer Protein (HEK293, Fc) is 1173 a.a., with molecular weight of 230-250 kDa.
  • HY-P78283
    SARS-COV-2 S Protein RBD (HEK293, His-Avi)

    S protein RBD; S glycoprotein RBD; Spike protein RBD

    Virus HEK293
    SARS-CoV-2 S1 Protein, in its Spike protein S1 form, initiates infection by attaching the virion to the cell membrane through host receptor interaction. Simultaneously, Spike protein S2' acts as a viral fusion peptide, revealing itself after S2 cleavage during virus endocytosis. SARS-COV-2 S Protein RBD (HEK293, His-Avi) is the recombinant Virus-derived SARS-COV-2 S protein RBD, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of SARS-COV-2 S Protein RBD (HEK293, His-Avi) is 214 a.a., with molecular weight of 32-42 kDa.
  • HY-P74445A
    SARS-CoV-2 S1 Protein (Omicron, B.1.1.529, C-His)

    SARS-CoV-2 Protein; SARS-CoV-2 Spike Protein

    Virus HEK293
    The SARS-Cov-2 S glycoprotein is a SARS-Cov-2 S glycoprotein. The amino acid sequence 1261-1267a.a of the SARS-Cov-2 S glycoprotein is transmembrane. The SARS-Cov-2 S glycoprotein is a highly glycosylated trimer, each of which consists of 1260 amino acids (residues 14-1273), divided into four structural domains: the n-terminal domain (NTD), the c-terminal domain (CTD, also known as the receptor-binding domain, RBD), and two subdomains (SD1 and SD2). SARS-CoV-2 S1 Protein (Omicron, B.1.1.529, C-His) is the recombinant Virus-derived SARS-CoV-2 S1 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of SARS-CoV-2 S1 Protein (Omicron, B.1.1.529, C-His) is 670 a.a., with molecular weight of ~130 kDa.
  • HY-P7436
    SARS-CoV-2 S1 Protein (HEK293)

    2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD

    Virus HEK293
    SARS-CoV-2 S1 Protein (HEK293) is the recombinant S1 protein produced in HEK293 cells.
  • HY-P72034
    SARS-CoV-2 Nucleocapsid Protein, Human (His)

    Nucleocapsid protein

    Human E. coli
    The SARS-CoV-2 nucleocapsid protein plays a crucial role in assembling the virion, forming the helical ribonucleocapsid (RNP), and interacting with the viral genome and membrane protein M. In addition to its structural function, it also enhances subgenomic viral RNA transcription and overall replication. SARS-CoV-2 Nucleocapsid Protein, Human (His) is the recombinant human-derived SARS-CoV-2 Nucleocapsid protein, expressed by E. coli , with N-6*His labeled tag. The total length of SARS-CoV-2 Nucleocapsid Protein, Human (His) is 419 a.a., with molecular weight of ~48 kDa.
  • HY-P7431
    SARS-CoV-2 S Protein RBD (194a.a, HEK293, His)

    2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD

    Virus HEK293
    SARS-CoV-2 S Protein RBD (HEK293, His) produced in HEK293 cells is a recombinant SARS-CoV S protein receptor-binding domain (RBD) with His tag.
  • HY-P7434
    SARS-CoV-2 S1 Protein (HEK293, mFc)

    2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD

    Virus HEK293
    SARS-CoV-2 S1 Protein (HEK293, mFc) is the recombinant 2019-nCoV S1 protein with C-mFc tag produced in HEK293 cells.
  • HY-P7435
    SARS-CoV-2 S1 Protein (HEK293, Fc)

    2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD

    Virus HEK293
    SARS-CoV-2 S1 Protein (HEK293, Fc) is the recombinant 2019-nCoV S1 protein with C-Fc tag produced in HEK293 cells.
  • HY-P78275
    SARS-CoV-2 3CLpro/3C-like protease Protein

    3C-like protease; 3CL Protease; 3CL-Mpro; 3CL Pro; COVID-19; M Proteinase; Mpro

    Virus E. coli
  • HY-P7431A
    SARS-CoV-2 S Protein RBD (194a.a, HEK293, C-His)

    2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD

    Virus HEK293
    SARS-CoV-2 S1 Protein, in its Spike protein S1 form, initiates infection by attaching the virion to the cell membrane through host receptor interaction. Simultaneously, Spike protein S2' acts as a viral fusion peptide, revealing itself after S2 cleavage during virus endocytosis. SARS-CoV-2 S Protein RBD (194a.a, HEK293, C-His) is the recombinant Virus-derived SARS-CoV-2 S protein RBD, expressed by HEK293 , with C-6*His labeled tag. The total length of SARS-CoV-2 S Protein RBD (194a.a, HEK293, C-His) is 194 a.a., with molecular weight of ~31.9 kDa.
  • HY-P7437
    Nucleocapsid Protein (His)

    2019-nCoV coronavirus NP Protein; 2019-nCoV np Protein; 2019-nCoV novel coronavirus Nucleoprotein Protein

    Virus E. coli
    Nucleocapsid Protein (His) expressed by E. coli systems. Nucleocapsid Protein is required for coronavirus RNA synthesis and has RNA chaperone activity.
  • HY-P70122
    SARS-CoV-2 PLpro Protein

    rReplicase polyprotein 1ab/2019-nCoV Papain-Like Protease; Papain-like Protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a

    Virus E. coli
    The multifunctional SARS-CoV-2 PP1ab protein is essential for viral RNA transcription and replication, utilizing proteases for multi-protein cleavage. It inhibits host translation by binding to the 40S subunit and blocks ribosomal mRNA entry channels, thereby hindering the antiviral response. SARS-CoV-2 PLpro Protein is the recombinant Virus-derived SARS-CoV-2 PLpro protein, expressed by E. coli , with tag free. The total length of SARS-CoV-2 PLpro Protein is 315 a.a., with molecular weight of ~34.0 kDa.
Cat. No. Product Name Effect Purity