Mannose-binding Protein
Mannose-binding protein (MBP, also known as mannose-binding lectin or MBL) is a calcium-dependent collectin that initiates the lectin pathway of complement activation. Circulating as oligomers of trimeric subunits assembled from collagen-like tails and carbohydrate-recognition heads, it binds mannose, fucose, and N-acetylglucosamine patterns displayed by bacteria, fungi, and viruses, while ignoring host glycosylation. Surface-bound MBL recruits the MASP-1 and MASP-2 serine proteases, generating the C4b2a convertase in the same fashion as the classical pathway. Common MBL2 gene variants sharply reduce serum levels, and MBL deficiency is associated with childhood respiratory infections and increased infection risk during immunosuppression, which has driven interest in MBL replacement research.
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Mannose-binding Protein Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Fòrmula: Human
- Peso molecular: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
