IL-4 Receptor
IL-4 Receptor (IL-4R) is a receptor for IL-4 and IL-13 and belongs to the type I cytokine receptor family, subfamily 4. IL-4R binds to the JAK1/2/3 STAT6 pathway and participates in the response to promote Th2 cell differentiation by binding to IL-4. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and T cell up-regulation of IL-5[1][2]. Among them, IL4RA is the main functional chain of IL-4R, a receptor of B cell stimulator (BSF) and an anti-inflammatory cytokine, which is highly expressed in activated T cells[3]. IL-4 RA is involved in the formation of two interleukin receptors in different cell types. The formation of type I receptor depends on the recruitment of IL-2Rγ chain by IL-4 RA and then binding to IL-4. The formation of type II receptor depends on the recruitment of IL-13Rα-1 chain by IL-4 RA to bind IL-4[4][5]. IL-4 RA produces a soluble form through alternate splicing or proteolysis that preserves ligand binding properties and inhibits IL-4 biological activity. The soluble subtype of IL-4 RA is produced by metalloproteinases on the cell surface through lyolytic cleavage (abscission)[6]. IL-4 RA plays an important role in Th2-biased immune response, replacement macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherosclerosis formation[7].
- [1]. Keegan AD, et al. An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth. Cell. 1994 Mar 11;76(5):811-20. [Content Brief]
- [2]. Nelms K, et al. The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol. 1999;17:701-38. [Content Brief]
- [3]. Keegan AD,et al. An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth. Cell. 1994 Mar 11;76(5):811-20. [Content Brief]
- [4]. Zurawski SM, et al. The primary binding subunit of the human interleukin-4 receptor is also a component of the interleukin-13 receptor. J Biol Chem. 1995 Jun 9;270(23):13869-78. [Content Brief]
- [5]. Rolling C, et al. IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells. FEBS Lett. 1996 Sep 9;393(1):53-6. [Content Brief]
- [6]. Jung T, et al. Soluble human interleukin-4 receptor is produced by activated T cells under the control of metalloproteinases. Int Arch Allergy Immunol. 1999 May;119(1):23-30. [Content Brief]
- [7]. Hage T, et al. Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface. Cell. 1999 Apr 16;97(2):271-81. [Content Brief]
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IL-4 Receptor Recombinant Proteins (16)
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- 1
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
