1. Recombinant Proteins
  2. IL-4R alpha/CD124 Protein, Human (HEK293)

IL-4R alpha/CD124 Protein, Human (HEK293)

Cat. No.: HY-P7220
Handling Instructions

IL-4R alpha/CD124 Protein, Human (HEK293) is a type I transmembrane protein that can bind interleukin-4 and interleukin-13.

For research use only. We do not sell to patients.

Protein Expression Service

Recombinant Proteins-MedChemExpress
Size Price Stock Quantity
10 μg $160 In-stock
Estimated Time of Arrival: December 31
50 μg $590 Get quote
100 μg   Get quote  
250 μg   Get quote  

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Publications Citing Use of MCE IL-4R alpha/CD124 Protein, Human (HEK293)

  • Technical Parameters

  • Properties

  • Documentation

Synonyms
rHuIL-4R; IL4R; IL-4RA; CD124
Species

Human

Source

HEK 293

Accession

P24394 (G24-H232)

Gene ID

3566

Molecular Weight

40-45 kDa

AA Sequence

GNMKVLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVRAWAQCYNTTWSEWSPSTKWHNSYREPFEQH

Biological Activity
The ED50 is <70 ng/mL as measured by TF-1 cells.
Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against PBS.

Endotoxin Level

<0.2 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O or PBS.

Storage & Stability

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Background

The effect of IL-4 signaling is mediated through the IL-4 receptor alpha chain (IL-4Rα). Upon binding to its ligand, IL-4Rα dimerizes either with the common gamma chain (γc) to produce the type-1 signaling complex located mainly on hematopoietic cells, or with the IL-13 receptor alpha 1 (IL-13Rα1) to produce the type-2 complex, which is expressed also on non-hematopoietic cells[1].

Documentation
References
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  • Dilution Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Product Name:
IL-4R alpha/CD124 Protein, Human (HEK293)
Cat. No.:
HY-P7220
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