NCAM-1/CD56
NCAM-1 (CD56) is a calcium-independent cell adhesion molecule of the immunoglobulin superfamily, with five extracellular Ig-like domains and two fibronectin type III repeats, encoded by NCAM1. Homophilic NCAM-NCAM binding links adjacent neural cells, and alternative splicing plus posttranslational polysialylation by ST8SIA enzymes modulate its adhesive strength; highly polysialylated NCAM promotes plasticity and neurite outgrowth. In the immune system, CD56 is the defining marker of natural killer cells and of CD56+ NK-like T cell subsets, and aberrant CD56 expression characterizes neuroendocrine tumors and multiple myeloma plasma cells. In oncology, CD56 immunostaining identifies neuroendocrine differentiation, and the anti-CD56 antibody-drug conjugate lorvotuzumab mertansine has been evaluated in neuroendocrine malignancies.
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NCAM-1/CD56 Recombinant Proteins (12)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
