1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Gutathione S-transferase

Gutathione S-transferase

Glutathione-S-transferases (GSTs) are a family of Phase II detoxification enzymes that catalyse the conjugation of glutathione (GSH) to a wide variety of endogenous and exogenous electrophilic compounds. GSTs are divided into two distinct super-family members: the membrane-bound microsomal and cytosolic family members. Microsomal GSTs are structurally distinct from the cytosolic in that they homo- and heterotrimerize rather than dimerize to form a single active site. Microsomal GSTs play a key role in the endogenous metabolism of leukotrienes and prostaglandins. Glutathione S-transferases (GSTs) function to protect cellular macromolecules from attack by reactive electrophiles. GSTs may be viable drug targets in disease states unrelated to cancer.

Gutathione S-transferase Related Products (11):

Cat. No. Product Name Effect Purity
  • HY-13634A
    Ezatiostat Inhibitor
    Ezatiostat (TER199 free base; TLK199) is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).
  • HY-111530
    GSTO1-IN-1 Inhibitor 98.32%
    GSTO1-IN-1 is a potent glutathione S-transferase omega 1 (GSTO1) inhibitor with an IC50 of 31 nM.
  • HY-13634B
    TLK117 Inhibitor 98.32%
    TLK117, the active metabolite of TLK199, selective inhibits Glutathione S-transferase P1–1 (GSTP1-1) with a Ki of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a Ki of 0.56 μM.
  • HY-126329
    AZD9898 Inhibitor
    AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma.
  • HY-N1963
    Curzerene Inhibitor
    Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression. Curzerene induces cell apoptosis.
  • HY-108538
    Ethacrynic acid D5 Inhibitor
    Ethacrynic acid D5 is a deuterium labeled Ethacrynic acid. Ethacrynic acid is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice.
  • HY-N1282
    Seneciphylline Activator
    Seneciphylline is a toxic pyrrolizidine alkaloid in Senecio plants. Seneciphylline significantly increases the activities of epoxide hydrase and glutathione-S-transferase but causes reduction of cytochrome P-450 and related monooxygenase activities.
  • HY-112534
    GSTO-IN-2 Inhibitor >98.0%
    GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.
  • HY-117143
    TK05 Inhibitor
    TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM.
  • HY-N1916
    Coniferyl ferulate Inhibitor
    Coniferyl ferulate, a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis, reverses multidrug resistance and downregulates P-glycoprotein. Coniferyl ferulate shows strong inhibition of human placental GST with an IC50 of 0.3 μM.
  • HY-13634
    Ezatiostat hydrochloride Inhibitor
    Ezatiostat hydrochloride (TER199;TLK199 hydrochloride) is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.