1. PI3K/Akt/mTOR
    Stem Cell/Wnt
  2. GSK-3

GSK-3

GSK-3 (Glycogen synthase kinase 3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. In mammals GSK-3 is encoded by two known genes, GSK-3 alpha (GSK3A) and GSK-3 beta (GSK3B). GSK-3 has recently been the subject of much research because it has been implicated in a number of diseases, including Type II diabetes (Diabetes mellitus type 2), Alzheimer's Disease, inflammation, cancer, and bipolar disorder. Phosphorylation of a protein by GSK-3 usually inhibits the activity of its downstream target. GSK-3 is active in a number of central intracellular signaling pathways, including cellular proliferation, migration, inflammation and immune responses, glucose regulation, and apoptosis.

GSK-3 Related Products (20):

Cat. No. Product Name Effect Purity
  • HY-10182
    CHIR-99021 Inhibitor 99.92%
    CHIR-99021 is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases.
  • HY-12012
    SB 216763 Inhibitor
    SB 216763 is potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor, with IC50 value of 34 nM.
  • HY-10512
    AR-A014418 Inhibitor 99.07%
    AR-A014418 is a selective and effective GSK3β inhibitor with an IC50 value of 104 +/- 27 nM; no significant inhibition on 26 other kinases.
  • HY-10580
    BIO Inhibitor 98.37%
    BIO is a potent and selective inhibitor of GSK-3 and CDK1-cyclinB complex with IC50s of 5 nM/320 nM/83 nM for GSK-3αβ/CDK1/CDK5, respectively.
  • HY-16294
    LY2090314 Inhibitor 99.06%
    LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 values of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β, respectively.
  • HY-10590
    TWS119 Inhibitor 98.35%
    TWS119 is an inhibitor of glycogen synthase kinase-3β (IC50 = 30 nM).
  • HY-15761
    AZD2858 Inhibitor 98.50%
    AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, inhibits tau phosphorylation at the S396 site, activates Wnt signaling pathway.
  • HY-13076
    CHIR-98014 Inhibitor 98.19%
    CHIR-98014 is a selective GSK3 inhibitor with IC50s of 0.65 nM and 0.58 nM for GSK-3α and GSK-3β; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
  • HY-13862
    AZD1080 Inhibitor 99.10%
    AZD1080 is a potent and selective GSK3 inhibitor.
  • HY-14872
    Tideglusib Inhibitor 99.81%
    Tideglusib is an irreversible GSK-3 inhibitor with IC50 of 5 nM and 60 nM for GSK-3βWT (1 h preincubation) and GSK-3βC199A (1 h preincubation), respectively.
  • HY-100207
    CP21R7 Inhibitor
    CP21R7 is a potent and selective GSK-3β inhibitor.
  • HY-15438
    SB 415286 Inhibitor 99.51%
    SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM.
  • HY-12302
    Kenpaullone Inhibitor 98.09%
    Kenpaullone is an ATP-competitive inhibitor of several CDKs as well as GSK-3β, with an IC50 value of 0.23 μM for GSK-3β and 0.4, 0.68, 0.85, and 0.47 μM for CDK1/cyclin B, CDK2/cyclin A, CDK5/p25, and lymphocyte kinase., respectively.
  • HY-11012
    TDZD-8 Inhibitor 99.07%
    TDZD-8(NP 01139) is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM); does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM.
  • HY-10182B
    CHIR-99021 trihydrochloride Inhibitor 99.02%
    CHIR-99021 trihydrochloride is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases.
  • HY-19807
    Indirubin-3'-monoxime Inhibitor 99.70%
    Indirubin-3'-monoxime is a powerful inhibitor of GSK-3β with IC50 of 22nM, also inhibits CDK1/5 (IC50 = 180/100 nM).
  • HY-12524
    Bikinin Inhibitor
    Bikinin(Abrasin) is a potent inhibitor of plant GSK-3/Shaggy-like kinase; activates BR signaling downstream of the BR receptor.
  • HY-12292
    IM-12 Inhibitor
    IM-12 is a potent GSK-3β inhibitor with IC50 of 53 nM; shows a significant activity in several biological tests which was comparable or even outplayed the effects of the known SB-216763.
  • HY-10182A
    CHIR-99021 monohydrochloride Inhibitor
    CHIR-99021 monohydrochloride is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases.
  • HY-13973A
    GSK-3 inhibitor 1 Inhibitor
    GSK-3 inhibitor 1 is a potent GSK-3 inhibitor.