1. PI3K/Akt/mTOR
    Stem Cell/Wnt
  2. GSK-3

GSK-3

Glycogen synthase kinase 3 (GSK-3) is a multifunctional serine/threonine kinase found in all eukaryotes. GSK-3 is one of the few signaling mediators that play central roles in a diverse range of signaling pathways, including those activated by Wnts, hedgehog, growth factors, cytokines, and G protein-coupled ligands. GSK-3 targets transcription factors, regulates the activity of metabolic and signaling enzymes, and controls the half-life of proteins by earmarking them for degradation. GSK-3 exists as two isoforms, GSK-3a (51 kDa) and GSK3b (47 kDa), which are encoded by distinct genes. These isoforms often have overlapping functions, but they do not always compensate for each other.

GSK-3 Isoform Specific Products:

  • GSK-3

  • GSK-3α

  • GSK-3β

GSK-3 Related Products (22):

Cat. No. Product Name Effect Purity
  • HY-10182
    CHIR-99021 Inhibitor 99.92%
    CHIR-99021 is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases.
  • HY-12012
    SB 216763 Inhibitor
    SB 216763 is potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor, with IC50 value of 34.3 nM for GSK-3α and GSK-3β, respectively.
  • HY-10590
    TWS119 Inhibitor >98.0%
    TWS119 is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway.
  • HY-14872
    Tideglusib Inhibitor 99.81%
    Tideglusib is an irreversible GSK-3 inhibitor with IC50 of 5 nM and 60 nM for GSK-3βWT (1 h preincubation) and GSK-3βC199A (1 h preincubation), respectively.
  • HY-10580
    BIO Inhibitor 98.03%
    BIO is a potent and selective inhibitor of GSK-3 and CDK1-cyclinB complex with IC50s of 5 nM/320 nM/80 nM for GSK-3αβ/CDK1/CDK5, respectively.
  • HY-16294
    LY2090314 Inhibitor 99.75%
    LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 values of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β, respectively.
  • HY-10512
    AR-A014418 Inhibitor
    AR-A014418 is a selective and effective GSK3β inhibitor with an IC50 value of 104 nM, and has no significant inhibition on 26 other kinases.
  • HY-12302
    Kenpaullone Inhibitor 98.09%
    Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3β, with IC50s of 0.4 μM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC50s of 0.68 μM, 7.5 μM, 0.85 μM, respectively.
  • HY-13862
    AZD1080 Inhibitor 99.10%
    AZD1080 is a potent and selective GSK3 inhibitor. AZD1080 inhibits recombinant human GSK3α and GSK3β with pKi (IC50) of 8.2 (6.9 nM) and 7.5 (31 nM), respectively.
  • HY-10182B
    CHIR-99021 trihydrochloride Inhibitor 99.02%
    CHIR-99021 trihydrochloride is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases.
  • HY-15761
    AZD2858 Inhibitor 99.24%
    AZD2858 is a potent, orally active GSK-3 inhibitor, with IC50s of 0.9 and 5 nM for GSK-3α and GSK-3β, respectively, used in the research of fracture healing.
  • HY-15438
    SB 415286 Inhibitor 99.88%
    SB 415286 is a potent and selective cell permeable inhibitor of GSK-3α, with an IC50 of 77.5 nM, and a Ki of 30.75 nM.
  • HY-19807
    Indirubin-3'-monoxime Inhibitor 99.70%
    Indirubin-3'-monoxime is a potent GSK-3β inhibitor, and a less potent inhibitor of 5-Lipoxygenase, with IC50s of 22 nM and 7.8-10 µM, respectively; also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC50s of 100 and 180 nM.
  • HY-100207
    CP21R7 Inhibitor 99.52%
    CP21R7 is potent GSK-3β inhibitor, with an IC50 of 1.8 nM; also shows inhibitory activitiy against PKCα, with an IC50 of 1900 nM.
  • HY-13076
    CHIR-98014 Inhibitor >98.0%
    CHIR-98014 is a potent, cell-permeable GSK-3 inhibitor with IC50s of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively; it shows less potent activities against cdc2 and erk2.
  • HY-15504A
    RGB-286638 free base Inhibitor 99.55%
    RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.
  • HY-12524
    Bikinin Inhibitor 99.82%
    Bikinin is a non-steroidal, ATP-competitive inhibitor of plant GSK-3/Shaggy-like kinases and activates BR (brassinosteroids) signaling.
  • HY-11012
    TDZD-8 Inhibitor 98.74%
    TDZD-8 is an inhibitor of GSK-3β, with an IC50 of 2 μM; shows less potent activities against Cdk-1/cyclin B, CK-II, PKA, and PKC, with all IC50s of >100 μM.
  • HY-12292
    IM-12 Inhibitor
    IM-12 is an inhibitor of GSK-3β, with an IC50 of 53 nM, and also enhances Wnt signalling.
  • HY-15504
    RGB-286638 Inhibitor
    RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.